English for doctors. Hematopoietic tissue (lecture notes)

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English for doctors. Hematopoietic tissue (lecture notes)

Lecture notes, cheat sheets

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LECTURE № 17. Hematopoietic tissue

Hematopoietic tissue is composed of reticular fibers and cells, blood vessels, and sinusoids (thin-walled blood channels). Myeloid, or blood cell-forming tissue, is found in the bone marrow and provides the stem cells that develop into erythrocytes, granulocytes, agranulo-cytes, and platelets. Red marrow is characterized by active hematopoiesis; yellow bone marrow is inactive and contains mostly fat cells. In the human adult, hematopoiesis takes place in the mar row of the flat bones of the skull, ribs and sternum, the vertebral column, the pelvis, and the proximal ends of some long bones. Erythropoiesis is the process of RBC formation. Bone marrow stem cells (colony-forming units, CFUs) differentiate into proerythroblasts under the influence of the glycoprotein erythropoietin, which is produced by the kidney.

Proerythroblast is a large basophilic cell containing a large spherical euchromatic nucleus with prominent nucleoli.

Basophilic erythroblast is a strongly basophilic cell with nucleus that comprises approximately 75% of its mass. Numerous cytoplasmic polyribosomes, condensed chromatin, no visible nucleoli, and continued hemoglobin synthesis characteristics of this cell.

Polychromatophilic erythroblast is the last cell in this line undergoes mitotic divisions. Its nucleus comprises approximately 50% of its mass and contains condensed chromatin which appears in a "checker-board" pattern. The polychnsia of the cytoplasm is due to the increased quantity of acidophilic hemoglobin combined with the basophilia of cytoplasmic polyribosomes.

Normoblast (orthochromatophilic erythroblast) is a cell with a small heterochromatic nucleus that comprises approximately 25% of its mass. It contains acidophilic cytoplasm because the large amount of hemoglobin and degenerating organelles. The pyknotic nucleus, which is no longer capable of division, is extruded from the cell.

Reticulocyte (polychromatophilic erythrocyte) is an immature acidophilic denucleated RBC, which still contains some ribosomes and mitochondria involved in the synthesis of a small quantity of hemoglobin. Approximately 1% of the circulating RBCs are reticulocytes.

Erythrocyte is the mature acidophilic and denucleated RBC. Erythrocytes remain in the circulation approximately 120 days and are then recycled by the spleen, liver, and bone marrow.

Granulopoiesis is the process of granulocyte formation. Bone marrow stem cells differentiate into all three types of granulocytes.

Myeloblast is a cell that has a large spherical nucleus containing delicate euchromatin and several nucleoli. It has a basophilic cytoplasm and no granules. Myeloblasts divide to form smaller pro-myelocytes.

Promyelocyte is a cell that contains a large spherical indented nucleus with coarse condensed chromatin. The cytoplasm is basophilic and contains peripheral azurophilic granules.

Myelocyte is the last cell in this series capable of division. The nucleus becomes increasingly heterochromatic with subsequent divisions. Specific granules arise from the Golgi apparatus, resulting in neu-trophilic, eosinophilic, and basophilic myelocytes.

Metamyelocyte is a cell whose indented nucleus exhibits lobe formation that is characteristic of the neutrophil, eosinophil, or basophil. The cytoplasm contains azurophilic granules and increasing numbers of specific granules. This cell does not divide. Granulocytes are the definitive cells that enter the blood. Neutrophilic granulocytes exhibit an intermediate stage called the band neutrophil. This is the first cell of this series to appear in the peripheral blood.

It has a nucleus shaped like a curved rod or band.

Bands normally constitute 0,5-2% of peripheral WBCs; they subsequently mature into definitive neutrophils.

Agranulopoiesis is the process of lymphocyte and monocyte formation. Lymphocytes develop from bone marrow stem cells (lymphoblasts). Cells develop in bone marrow and seed the secondary lympho-id organs (eg, tonsils, lymph nodes, spleen). Stem cells for T cells come from bone marrow, develop in the thymus and, subsequently, seed the secondary lymphoid organs.

Promonocytes differentiate from bone marrow stem cells (mono-blasts) and multiply to give rise to monocytes.

Monocytes spend only a short period of time in the marrow before being released into the bloodstream.

Monocytes are transported in the blood but are also found in connective tissues, body cavities and organs.

Outside the blood vessel wall, they are transformed into macrophages of the mononuclear phagocyte system.

Thrombopoiesis, or the formation of platelets, occurs in the red bone marrow.

Megakaryoblast is a large basophilic cell that contains a U-shaped or ovoid nucleus with prominent nucleoli. It is the last cell that undergoes mitosis.

Megakaryocytes are the largest of bone marrow cells, with diameters of 50 mm or greater. They undergo 4-5 nuclear divisions without concomitant cytoplasmic division. As a result, the megakaryocyte is a cell with polylobulated, polyploid nucleus and abundant granules in its cytoplasm. As megakaryocyte maturation proceeds, "curtains" of platelet demarcation vesicles form in the cytoplasm. These vesicles coalesce, become tubular, and eventually form platelet demarcation membranes. These membranes fuse to give rise to the membranes of the platelets.

A single megakaryocyte can shed (ie, produce) up to 3,500 platelets.

new words

reticular - mesh

sinusoids - sinusoids

granulocytes - granulocytes

agranulocytes - agranulocytes

active - active

yellow - yellow

glycoprotein - glycoprotein

erythropoietin - erythropoietin

large - large

amount - the amount

hemoglobin - hemoglobin

degenerating - degeneration

capable - capable

division - division

spherical - spherical

indented - jagged

condensed - compressed

chromatin - chromatin

Remember the following frozen phrases.

to play _ chess to play the piano to play _ football to play the guitar out of _ doors

Remember that before addressing the article is omitted.

E. g. What are you doing, _ girls?

Fill in the blanks where necessary.

1. Do you play... piano?

2. There is... big black piano in our living-room.

3. It is at... wall to... left of... door opposite... sideboard.

4. My mother likes to play. piano.

5. She often plays... piano in... evening.

6..boys like to play... football.

7. What do you do in... evening? - I often play... chess with my grandfather.

8. Where are... children? - Oh, they are out of... doors... weather is fine today.

9. They are playing... badminton in... yard.

10. What... games does your sister like to play?

11. She likes to play... tennis.

12. Do you like to play... guitar?

13. What... color is your guitar?

14. When we want to write... letter, we take... piece of... paper and... pen.

15. We first write our... ad dress and... date in... right-hand corner.

16. Then on... left-hand side we write... greeting.

17. We must not forget to leave... margin on... left-hand side of... page.

18. On... envelope we write... name and address of... person who will receive it.

19. We stick... stamp on... top of right-hand corner.

20. We posted... letter.

Answer the questions.

1. What is hematopoietic tissue composed of?

2. Where is myeloid found?

3. How is red marrow characterized?

4. What does yellow bone marrow contain?

5. Where does hematopoiesis take place in the human adult?

6. What is erythropoiesis?

7. What is myeloblast?

8. What is band neutrophil?

9. How long are megakaryocytes?

10. How many platelets can a single megakaryocyte shed?

11. Make the sentences of your own using the new words (10 sentences).

12. Find the definite and indefinite articles in the text.

Author: Elena Belikova

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