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Infectious diseases. Listeriosis. Clinic. Diagnostics. Treatment (most important) Directory / Lecture notes, cheat sheets Table of contents (expand) 37. Listeriosis. Clinic. Diagnostics. Treatment Clinical manifestations. Listeria can cause meningitis or sepsis in newborns and young children. Listeriosis can present with pneumonia, endocarditis, localized abscesses, papular or pustular skin changes, conjunctivitis, and urethritis. With an early onset in a live-born child, the disease in the 1st week of life is manifested by the formation of whitish granulomas on the mucous membranes, widespread papular or petechial rashes on the skin, as well as anorexia, lethargy, vomiting, jaundice, respiratory disorders, infiltrative changes in the lungs, myocarditis, cyanosis, hepatomegaly. Often septicemia or meningitis develops. With a late onset of the disease, the child looks healthy at birth, but within the 1st month of life he develops septicemia or meningitis, which manifests itself as ordinary purulent meningitis. Older children may develop meningitis or meningoencephalitis. Clinically, meningitis does not differ from that in other purulent infections, but in some cases it begins subacutely - with headaches, a slight increase in body temperature and a feeling of weakness a few days before the onset of signs of CNS damage. Oculo-glandular syndrome is characterized by keratoconjunctivitis, corneal ulceration, and regional lymphadenitis. Listeriosis can also present with pneumonia, a flu-like condition (especially in pregnant women), endocarditis, localized abscesses, conjunctivitis, urethritis, and papular or pustular skin changes. For the final diagnosis, laboratory confirmation is necessary after performing: 1) bacteriological research methods for the purpose of isolating listeria, taking cultures of mucus from the throat, nose, blood, cerebrospinal fluid and other pathological materials on a normal nutrient medium or using a biological sample; 2) serological research methods, which are the main ones in the diagnosis of listeriosis (RA, RSK, RPGA); 3) intradermal test with listeriosis antigen to confirm the diagnosis. Treatment. The drug sensitivity of different strains of Listeria is different. Most of them are sensitive to erythromycin, tetracycline, penicillin G and ampicillin. Many strains are also sensitive to chloramphenicol. Treatment usually begins with the appointment of ampicillin in the usual doses, taking into account the form of the disease and the age of the patient. It is necessary to conduct studies of the sensitivity of the pathogen during treatment and make appropriate changes to it, if necessary. Some strains of L. monocytogenes are resistant to ampicillin; in these cases, treatment with a combination of ampicillin and gentamicin is quite effective. Author: Pavlova N.V. << Back: Listeriosis. Etiology. Epidemiology. Pathomorphology and pathogenesis >> Forward: anthrax We recommend interesting articles Section Lecture notes, cheat sheets: ▪ Psychology of Personality. Crib ▪ History of Pedagogy and Education. Crib See other articles Section Lecture notes, cheat sheets. Read and write useful comments on this article. Latest news of science and technology, new electronics: The existence of an entropy rule for quantum entanglement has been proven
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