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Infectious diseases. Diphtheria. Clinic. Diagnostics. Treatment (most important) Directory / Lecture notes, cheat sheets Table of contents (expand) 27. Diphtheria. Clinic. Diagnostics. Treatment Clinical manifestations. The symptomatology of diphtheria is determined by the localization of the infection, the immunological status of the macroorganism and the severity of toxemia. The incubation period is 1-6 days. Classification: 1) diphtheria of the nose occurs mainly in young children. Initially, it is characterized by mild rhinorrhea in the absence of general disorders. Gradually, discharge from the nose becomes serous-bloody in color, and then mucopurulent; 2) diphtheria of the tonsils and pharynx - a more severe form of the disease. The onset of the disease is characterized by an inconspicuous, gradual increase in body temperature, anorexia, malaise and pharyngitis. After 1-2 days, films appear in the throat, the prevalence of which depends on the immune status of the patient. Cervical lymphadenitis in some cases is accompanied by swelling of the soft tissues of the neck, in others it can be very pronounced, resembling a bull's neck. The course of pharyngeal diphtheria depends on the prevalence of films and the amount of toxin produced; 3) diphtheria of the larynx develops with the spread of films from the tonsils and from the nasopharynx. Clinical symptoms resemble a picture of a common infectious croup: noisy labored breathing, increasing stridor, wheezing and dry cough; 4) diphtheria of the skin is characterized by ulcers with clear edges and a bottom covered with a diphtheria film; 5) diphtheria of the conjunctival membrane is usually limited to a local process, with reddening of the eyelids, their swelling and film formation; 6) ear diphtheria is characterized by otitis externa with long-term persistent and foul-smelling purulent discharge. Diagnosis. Diphtheria is diagnosed: 1) based on clinical data; 2) when confirming the isolation of the pathogen; 3) using the method of fluorescent antibodies. Treatment. The basis of treatment is the neutralization of free diphtheria toxin and the destruction of the pathogen with antibiotics. The only specific therapeutic agent is diphtheria antitoxin, obtained from the serum of hyperimmunized horses. Antitoxin should be given intravenously as early as possible and in amounts sufficient to neutralize all circulating toxin in the body. Doses of antitoxin are selected empirically: in mild forms of diphtheria of the nose or pharynx, 40 units are prescribed, and in more severe forms, 000 units. A dose of 80 units is prescribed for the most severe forms of diphtheria of the pharynx and larynx. Antibiotics (erythromycin and penicillin, amoxicillin, rifampicin, clindamycin) are prescribed to stop further production of the toxin by the diphtheria bacillus. Author: Pavlova N.V. << Back: Diphtheria. Etiology. Epidemiology. Pathogenesis and pathomorphology >> Forward: Pertussis We recommend interesting articles Section Lecture notes, cheat sheets: ▪ History and theory of religions. Crib See other articles Section Lecture notes, cheat sheets. Read and write useful comments on this article. Latest news of science and technology, new electronics: The existence of an entropy rule for quantum entanglement has been proven
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