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45. Clinical picture and diagnosis of chronic enteritis

clinical picture. The clinical picture of chronic enteritis consists of local and general enteric syndromes. The first is due to a violation of the processes of parietal (membrane) and cavity digestion (maldigestion). Patients complain of flatulence, pain in the paraumbilical zone, bloating in the form of a cap, loud rumbling, diarrhea, less often constipation. Palpation reveals pain in the mesogastrium, as well as on the left and above the navel (positive symptom of Porges), splashing noise in the region of the caecum (Obraztsov's symptom). Feces acquire a clayey appearance, polyfecalia is characteristic.

General enteral syndrome is associated with impaired absorption of food ingredients (malabsorption), resulting in disorders of all types of metabolism, changes in homeostasis. Characterized by multifaceted metabolic disorders, primarily protein, which is manifested by a progressive loss of body weight. Changes in carbohydrate metabolism are less pronounced, which is manifested by bloating, rumbling in the abdomen and increased diarrhea while taking dairy products. To a large extent, the deficiency of body weight in patients is due not only to protein, but also to lipid imbalance. Changes in lipid metabolism are closely related to metabolic disorders of fat-soluble vitamins and minerals (calcium, magnesium, phosphorus). The characteristic signs of calcium deficiency are a positive symptom of the muscle roller, convulsions, recurrent "unmotivated" bone fractures, osteoporosis, osteomalacia.

Diagnosis and differential diagnosis. A general blood test reveals micro- and macrocytic anemia, an increase in ESR, and in severe cases - lympho- and eosinopenia. If the disease is of parasitic origin, lymphocytosis and eosinophilia may be observed in the blood.

A scatological examination reveals an intestinal type of steatorrhea due to fatty acids and soaps, creatorrhea, amylorrhea. The content of enterokinase and alkaline phosphatase in feces increases. The daily mass of feces increases significantly.

A biochemical blood test reveals hypoproteinemia, hypoalbuminemia, hypoglobulinemia, hypocalcemia, decreased levels of magnesium, phosphorus, and other microelements, disturbances in electrolyte metabolism in the form of decreased sodium and potassium levels.

The morphological picture of a mild form of chronic enteritis is characterized by thickening of the villi, their deformation, a decrease in the depth of the notches, a decrease in the tone of smooth muscles, subepithelial edema, degenerative changes in the surface of the epithelium, thinning of the brush border of cells, a decrease in the number of goblet cells in the region of the villi, an increase in the number of crypts, infiltration of the own layer mucosa with lymphoplasmacytic elements, a decrease in Paneth cells in the area of ​​the bottom of the crypts.

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