Leash knot based on the snake knot. Travel Tips

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Leash knot based on the snake knot. Travel Tips

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Leash knot based on snake knot - this is a complex but reliable way of tying a transverse leash to a fishing line.

Before tightening the snake knot made on the fishing line, insert the end of the leash with the figure eight tied into its middle. When tightening the snake knot, both parts of it will converge and securely clamp the leash in front of the figure eight.

Rice. 132. Leash based on a snake knot

Author: Skryagin L.N.

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Metabolic weight gain switch 04.09.2015

Researchers at MIT and Harvard Medical School have discovered a new way to control human metabolism and tell adipocytes, or fat cells, when to store and when to burn fat.

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Studies show that a single nucleotide genetic difference can lead to obesity or overweight. In individuals at risk, the nucleotide base replaces thymine with cytosine, which triggers the action of IRX3 and IRX5. Those, in turn, turn off the process of thermogenesis, which leads to the accumulation of lipids and, over time, to obesity.

By altering this nucleotide using the CRISPR/Cas9 system, a technology that allows precise changes to the DNA sequence, scientists can replace cytosine with thymine and thus turn off IRX3 and IRX5, restore thermogenesis to a safe level, and reduce lipid accumulation.

Suppressing the actions of the IRX3 gene in mice resulted in significant changes in the body's energy balance, reduction in weight and all major fat stores, and resistance to high-fat diets.

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