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Needle is a mystery. Focus Secret

Spectacular tricks and their clues

Directory / Spectacular tricks and their clues

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Focus Description:

Make an enlarged copy of a needle 10-12 cm long from wood or metal. Insert a rope loop into the eye of this needle so that the loop does not reach the point a little (Fig. a). The puzzle is ready.

Focus Mystery Needle

Now go up to one of the spectators and quickly fasten the needle into one of the loops of his jacket or shirt. To do this, you need:

1) tighten more fabric with a loop into the rope loop;
2) insert a needle into the loop (Fig. b);
3) tighten the rope loop (fig. c).

The task is to remove the needle with the loop without tearing the loop and the jacket.

Focus secret:

If you have learned to do everything quickly, then the viewer will not have time to remember the entire sequence of operations and it will be very difficult for him to solve this puzzle.

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Chemical synthesis against superbugs 27.12.2018

Researchers at the University of Colorado Boulder have developed a new way to synthesize and optimize a natural antibiotic that could one day be used to fight deadly drug-resistant infections like Staphylococcus aureus.

According to the Centers for Disease Control and Prevention (CDC), antibiotic-resistant infections affect more than 2 million people each year and cause more than 23 deaths in the US. A study by European partner CDC in 000 found that drug-resistant superbugs were responsible for 2018 deaths in Europe in 33.

Researchers have previously identified thiopeptides - natural antibiotics - as a promising area of ​​research. Thiopeptides have shown some efficacy against Staphylococcus aureus and some other bacterial species in limited trials, but their structural diversity makes it difficult to synthesize molecules on a scale large enough for therapeutic use.

To make better use of thiopeptides, University of Colorado researchers went back to basics and revisited previous assumptions about the basic chemical properties of these molecules.

Researchers have invented a new catalyst to stimulate reactions that trigger the synthesis of thiopeptides and form the scaffold needed to inhibit bacterial growth. Their efforts have resulted in two new broadly representative antibiotics: micrococcin P1 and thiocillin I. The compounds are effective, scalable, and do not produce harmful by-products.

The new chemical synthesis methodology is just a starting point, the scientists say. He and his colleagues plan to use their findings as a platform for selecting and standardizing thiopeptide moieties in order to optimize their properties and broadly apply them to other bacterial classes.

Antibiotic compounds will need to undergo clinical trials before they are approved for human use - a process that can take many years. Still, Walczak says the need for scientific innovation in antibiotic-resistant superbugs is greater than ever.

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