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What French writer could receive letters that did not contain street and house numbers? Detailed answer

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What French writer could receive letters that did not contain street and house numbers?

In his last years, the writer Victor Hugo lived in a mansion on a Parisian street, which during his lifetime was called Victor Hugo Avenue. As a return address on the letters, the writer simply indicated: "Monsieur Victor Hugo on his avenue in Paris."

Authors: Jimmy Wales, Larry Sanger

 Random interesting fact from the Great Encyclopedia:

Which artist's paintings correspond to the mathematical description of turbulent flows?

Mathematicians who studied Van Gogh's paintings came to the conclusion that the swirls on some of his canvases quite accurately describe turbulent air flows invisible to the eye. This is expressed in the fact that the greater or lesser brightness of the points in the patterns is proportional to the velocities of the flow points in the corresponding coordinates in the mathematical modeling of turbulence. Scientists also note that similar paintings, including the famous Starry Night, were painted by Van Gogh during periods of mental instability.

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FGF21 injection helps sober up 13.03.2023

American researchers sobered mice by injection of the hormone FGF21, which reacts to the introduction of ethanol into the body. The connection allowed the animals to regain consciousness and coordination of movements twice as fast.

The FGF21 hormone is produced by the liver under the influence of a number of stress factors, such as starvation, lack of protein, or the action of ethanol. Previous studies have shown that the compound protects the liver from damage due to alcohol consumption, as well as reduces alcohol cravings and encourages drinking more fluids to prevent dehydration. Behavioral change means that the action of the hormone crosses the blood-brain barrier to the brain. Scientists at the University of Texas Southwestern Medical Center and colleagues decided to clarify the mechanism of its action.

First, the scientists heavily ethanoled two groups of mice - normal and blocked by the hormone FGF21. Although within 15-20 minutes they all became intoxicated and lost the ability to navigate in space, it took 1,5 hours longer for the modified animals to recover the reaction. At the same time, the rate of elimination of alcohol from the blood of animals was the same. Therefore, FGF21 protects against the consequences of ethanol consumption, but does not affect its metabolism.

In the next experiment, an hour after drinking, when the mice were already unconscious, half were given an injection of the hormone. As a result, consciousness and orientation in space recovered 1,5 hours faster than those who did not receive injections, and this is equal to a reduction in the time of intoxication by about 50 percent. The action of FGF21 appeared to be specific to ethanol, as it did not promote sobering after sedative compounds such as ketamine, diazepam, or pentobarbital.

The researchers found that the effect of FGF21 is due to its effect on the noradrenergic neurons in the locus coeruleus - parts of the brain that regulate arousal and alertness. This means that targeting these neurons, mimicking the action of FGF21, could help bring people out of high inebriation. But whether the mechanism of the hormone will work in humans in the same way as in mice should be clarified in the following studies.

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