John of Damascus. The most famous aphorisms

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APHORISMS OF FAMOUS PEOPLE
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Aphorisms of famous people. John of Damascus

Aphorisms of famous people

Free library / Aphorisms of famous people

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John of Damascus. The most famous aphorisms

The greedy soul is the beginning of all evil deeds.
Anyone who plots against his neighbor will fall into the ditch he has dug.
Must keep the secrets of his friends. He who does not keep a secret dishonors his conscience and shames his confidence.
Those who start a war themselves fall into their networks.
It is better to win with ingenuity and intelligence than with resistance.
Who is content with little, lives a carefree life.
Whoever strives for good must be ready to endure evil.
There is nothing stronger than good advice and nothing more harmful than a bad deed.
Patience and humility are necessary for both peace and war.

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Oxidizing molecules slow down aging 08.11.2020

Aggressive oxidizing molecules, or oxygen radicals, damage the cell's DNA, proteins and lipids, so that there seems to be no benefit from them. These oxidizing agents are inevitably formed during normal biochemical reactions, and cells have special enzymes that neutralize oxygen radicals. However, it happens that more of them are formed than usual, or that those enzymes that neutralize them begin to work poorly - and then oxidative stress occurs in the cell. It is believed that oxidative stress is one of the main causes of aging, and that many chronic diseases occur due to aggressive oxygen oxidants.

However, oddly enough, they can also be useful. For example, hydrogen peroxide, which is very unstable and easily decomposes with the formation of those same radicals - and so, hydrogen peroxide slows down aging. How he does it, found out the staff of the Technical University of Chalmers and the University of Gothenburg. They studied yeast and its Tsa1 enzyme, which serves as one of the antioxidant enzymes that neutralize hydrogen peroxide. But it turned out that Tsa1, although considered an antioxidant, does not significantly reduce peroxide levels. But it plays an important role in other processes.

It is known that restriction in calories prolongs the life of a wide variety of living organisms, from yeast to monkeys. Obviously, certain signaling proteins are triggered here, which receive information that there are fewer calories entering the cell and pass it on to other proteins, these others to third ones, etc., so that all molecular processes in the cell are reconfigured so that the time cell life is lengthened. Tsa1 turned out to be one of those signaling enzymes that assess calorie levels.

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To slow down aging, Tsa1 does not need a lot of peroxide, that is, there is no contradiction with the fact that an excess of oxygen radicals is dangerous for the cell. But a certain amount of peroxide is still needed, without it the cell will not be able to switch its metabolism to an energy-saving mode. In fact, this is not the first work that talks about the benefits of moderate amounts of oxygen radicals. There is evidence that they inhibit the growth of tumors, and that the well-known antidiabetic drug metformin prolongs the life of roundworms also with the help of radicals.

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