Hydraulic pipe bender. Drawing, description

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Hydraulic pipe bender. home workshop

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The main element of such a tool is a hydraulic jack used for hanging trucks. The lift is rigidly fixed on a steel plate - the base of the fixture. An aluminum alloy mandrel is put on the jack rod, and stops are fixed on the base.

It is advisable to make several mandrels of different curvature.

Hydraulic Pipe Bender

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Created a genetic scheme 21.10.2012

Bioengineers at the Massachusetts Institute of Technology have created a highly complex genetic blueprint using genes found in the Salmonella bacterium.

Using genes as parts of a constructor, scientists have the ability to create synthetic constructs that can perform various functions. For example, scientists at MIT have previously created bacteria that can react to light and take "photographs," as well as microorganisms that can detect low oxygen levels and high cell density (phenomena found in tumors). However, most of these projects use a small number of known parts of the genome, which does not allow the creation of complex schemes.

To increase the complexity of the circuits, scientists need components that will not interfere with each other. The fact is that, unlike electronic circuits on a silicon crystal, biological circuits in a cell cannot be physically isolated from each other. In a living cell, the cellular mechanisms for reading genes and synthesizing proteins are mixed together, and the bioengineer must take into account the possible incompatibility of different parts of the "constructor". To solve this problem, scientists carefully studied the Salmonella bacterium. This bacterium has a well-defined pathway for the introduction of proteins into human cells, making it an ideal sample for research.

As a result, 60 different versions of this pathway were found in other types of bacteria, and it turned out that most of the proteins involved in each of them were very different and did not interfere with each other. Thus, bioengineers received a lot of new details for their "constructor". In this case, to reduce crosstalk between several components of the future circuit, the method of directed evolution was used, i.e. mutation of genes to create thousands of their variants and select the most suitable ones.

MIT scientists have done a lot of work and have come up with a synthetic circuit that can detect the presence of four different molecules. This scheme can be used to program living cells to detect certain chemicals. In the future, such complex circuits can perform a variety of functions and control living cells.

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