Geography, geology, ecology - Lakes of Russia. Crosswordist's Handbook

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Geography, geology, ecology / Geography / Lakes of Russia

(4)

VIVA - Krasnoyarsk Territory

VOGHE - Vologda region

KETA - Krasnoyarsk Territory

LAMA - Krasnoyarsk Territory

LACHA - Arkhangelsk region

NEVO - the old Russian name for Lake Ladoga

NERO - Yaroslavl region

PENO - Tver region

CHANNY - Novosibirsk region, endorheic nomadic lake

(5)

AGATA - Siberia

BAUNT - Buryatia

WHITE - Vologda region

VOLGO - Tver region

MANYCH - Republic of Kalmykia

OREL - Khabarovsk Territory

ORNO (Voron) - Pskov region

Sarpa - Republic of Kalmykia

SENEZH - Moscow region

UDYL - Khabarovsk Territory

KHANKA - Primorsky Krai

KHASAN - Primorsky Krai

(6)

BAIKAL - Eastern Siberia, the deepest lake in the world

BUSANI - Republic of Buryatia

MSTINO - Tver region

PYASINO - Krasnoyarsk Territory

SANDAL - Republic of Karelia

TAIMYR - Krasnoyarsk Territory

TEPLOOE - Pskov region

EVORON - Khabarovsk Territory

Elton - Volgograd region, brackish lake

YAMTUBO - Tyumen region

(7)

VELYKOE - Tver region

ILMEN - Novgorod region

IMANDRA - Murmansk region

PYAOZERO (Pyavozero) - Republic of Karelia

SARTLAN - Novosibirsk region

SELIGER - Tver, Novgorod region

TUNAICHA - Sakhalin region, salt lake

CHUDSKOE (Peypsiyarv) - Pskov region

(8)

VYGOZERO - Republic of Karelia

DEEP - Eastern Siberia

KOVZHSKOE - Vologda region

LOVOZERO - Murmansk region

ONEZHSKOE - Republic of Karelia, Leningrad, Vologda regions, relict lake

PLESHCHEEVO (Pereslavskoe) - Yaroslavl region

SEGOZERO - Republic of Karelia

TELETSKOE (Altynkol) - Republic of Altai

TOPOZERO - Republic of Karelia

UMBOZERO - Murmansk region

(9)

BASKUNCHAK - Astrakhan region, salt lake

GALICHSKOE - Kostroma region

KOVDOZERO - Murmansk region, now a reservoir

KUBENSKOE - Vologda region

Ladoga (Nevo) - Republic of Karelia, Leningrad region, relict lake

PSKOVSKOE - Pskov region

SEBEZHSKOE - Pskov region

(10)

VALDAISKOE - Novgorod region

KOLVITSKOE - Murmansk region

HANTAISKOE - Krasnoyarsk Territory

CHUKHLOMSKOE - Kostroma region

(12)

KULUNDINSKOE - Altai Territory

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American geneticists have learned how to remove DNA fragments of the human immunodeficiency virus from DNA using the CRISPR/CAS "spot" genome editing system, which was originally used by bacteria to protect against retroviruses related to HIV. This paves the way for the creation of a fundamentally new vaccine against the disease, the article says.

"The main advantage of this technology is not only that we can destroy the viral DNA that integrates itself into our genome, but also that it can be used to prevent HIV. By destroying the virus at the earliest stages of its life cycle, we can completely prevent infection cells in much the same way that conventional vaccines work," said Juan Belomonte of the Salk Institute in La Jolla, USA.

According to RIA Novosti, Belmonte and his colleagues have taken a big step towards creating a "genetic" HIV vaccine by experimenting with the recently created CRISPR / CAS system, which allows you to randomly delete and replace individual genes and DNA fragments.

We can say that such an application is a kind of "return to the roots" for this system - it originally developed inside bacteria hundreds of millions of years ago precisely to protect against retroviruses, and only in 2012 Feng Zhang and his colleagues adapted it to change genome of multicellular organisms.

Belmonte's group analyzed the structure of the viral DNA and prepared a set of special markers in the form of short RNA molecules that bind to the genetic sequence of the virus, marking those fragments of the genome that CRISPR/CAS was supposed to remove. The scientists tested the work of these marks and the genome editing system itself on lymphocytes and other cells of the immune system that were already infected with HIV.

As the experiment showed, even the first version of these RNA labels was quite successful - it cleared about 72% of the cells from all traces of the virus. According to scientists, she coped well not only with recently penetrated into the cell of HIV, but also with deep-hidden "sleeping" copies of the virus.

CRISPR/CAS showed itself best of all as a tool for disease prevention - all immune cells, pre-treated with RNA and "genetic editor" molecules, completely avoided infection.

Today, Belmonte and his colleagues are working on the creation of several new sets of RNA tags that will cover more varieties of HIV, which in the future will allow to destroy all particles and copies of the virus in human DNA, thereby preventing its further evolution and mutation. While biologists do not know if HIV can adapt to CRISPR/CAS and how long this process will take, they are working on maximizing the effectiveness of such a vaccine to prevent such an outcome.

Recently, American researchers have introduced a new drug against HIV infection. It blocks two receptors located on the surface of the virus, through which it enters the cells of the immune system.

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