Women's brains age more slowly. Free Technical Library News

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Women's brains age more slowly

16.11.2019

American researchers scanned the brains of more than 200 adults, analyzing their metabolic rate, which is known to change with age. As a result, the scientists found that the brains of women were on average three years younger than the brains of men with the same chronological age.

Experts suggest that having a younger brain provides women with some degree of resilience to the changes associated with aging. This, in turn, may help explain why women experience slower cognitive decline with age than men.

In the new study, experts led by Dr. Manu Goyala, assistant professor of radiology at the Washington University School of Medicine in St. Louis, scanned the brains of 121 women and 84 men, aged 20 to 82. They then created a machine algorithm based on data about the men's age and their brain metabolism. After that, the scientists entered data about women into the algorithm and programmed it to calculate the "metabolic age" of women. They found that, based on data from men, the algorithm calculated that the "metabolic age" of the women's brains was 3,8 years younger than their chronological age.

For the next step, the scientists created an algorithm based on data from women and programmed it to calculate the "metabolic age" of the men's brains. The algorithm determined that the men's brains were about 2,4 years older than their actual chronological age.

The main source of fuel for the brain is glucose. When people are younger, they release more glucose during a metabolic process called "aerobic glycolysis," which is thought to help brain development and maturation, including brain cell growth. But closer to 60 years, aerobic glycolysis reaches a very low level.

More research is now needed to better understand how the difference in "metabolic age" of the brains of men and women affects the risk of diseases such as Alzheimer's, scientists say.

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