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Link between zinc deficiency and hypertension

26.01.2019

Zinc deficiency can cause high blood pressure (hypertension) by changing the way the kidneys regulate sodium.

Zinc deficiency is common in people with chronic conditions such as type 2 diabetes and chronic kidney disease. People with low zinc levels are also at an increased risk of hypertension. The way the kidneys either excrete sodium into the urine or reabsorb it into the body—especially through a pathway called the sodium chloride cotransporter (SCH)—also plays a role in blood pressure control. Less sodium in the urine usually corresponds to higher blood pressure. Recent studies have shown that zinc may help regulate proteins that in turn regulate CCH, but a direct link between zinc deficiency-induced hypertension has not been investigated.

The researchers compared zinc-deficient male mice with healthy mice with normal zinc levels. Mice deficient in zinc developed high blood pressure and a corresponding decrease in urinary sodium excretion. The control group did not experience the same changes. A small group of zinc-deficient mice received a zinc-rich diet throughout the study. Once the zinc levels in the animals reached adequate levels, blood pressure began to fall and urine sodium levels rose.

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The lightest isotope of magnesium 28.12.2021

In collaboration with an international team of researchers, Michigan State University has created the world's lightest version of magnesium.

The record-breaking isotope magnesium-18 is produced at the National Superconducting Cyclone Laboratory (NSCL) and is so unstable that it decays before scientists can measure it directly or detect it in nature. Therefore, using a particle accelerator, physicists created it in the laboratory in an attempt to understand how atoms are arranged and where the elements of the universe come from. This will help predict what happens in extreme space environments that may never be directly reproduced or measured from Earth.

All magnesium atoms have 12 protons inside the nucleus. Previously, the lightest version of magnesium had 7 neutrons, giving a total of 19 protons and neutrons. To get magnesium-18, which is one neutron lighter, the team took magnesium-24.

The cyclotron accelerated a beam of magnesium-24 nuclei to about half the speed of light and aimed it at its target: a beryllium metal foil.

The collision produced many different isotopes more easily than magnesium-24. Of these, magnesium-20 was isolated, the decay period of which is tenths of a second. During this time, the team had to force the resulting isotope to collide with another beryllium target at a distance of about 30 meters. This is how magnesium-18 appeared, which exists for about a sextillionth of a second. This is so small that the isotope is not masked by electrons to become a full atom before decay, and exists as a bare nucleus. In fact, in such a short period of time, magnesium-18 does not leave the beryllium target and decays inside it.

Scientists only characterized the clear signs of a new isotope. Magnesium-18 first ejected two protons from its core to become neon-16, which then emitted two more protons to become oxygen-14. By analyzing the protons and oxygen that left the target, the team determined the properties of magnesium-18.

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