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Established the connection of odors with memories

06.08.2018

Neuroscientists at the University of Toronto have described how the brain works to form vivid memories that include smells and associated associations.

The process of forming complex memories is associated with the interaction of the hippocampus and the anterior olfactory nucleus (anterior olfactory nucleus, AON), located in the forebrain. The hippocampus is responsible for the consolidation of memories, that is, the process of their transition from short-term memory to long-term memory. The hippocampus also provides spatial memory - stores information that allows you to navigate the terrain. AON plays an important role in the perception of aromas, but remains poorly understood.

To investigate the role of the AON and the hippocampus in memory formation, the authors of the new work used the tendency of mice to carefully sniff unfamiliar odors and pay little attention to familiar odors. When mice forget a certain smell, it again begins to arouse interest in rodents.

During the experiments, the animals were placed in cages containing containers with various flavors: the smells of garlic, banana, coffee, and other products. At the first stage of the experiment, the mouse was placed in a cage with two containers with different odors, then the animal was placed in a medium with two identical samples. Rodents, in which scientists artificially "turned off" the neural pathways connecting the AON and the hippocampus, studied both duplicate odors for the same length of time - they did not remember the first sample. The control group of mice quickly identified the repetition and did not pay attention to the second container.

In the following experiments, mice were attracted not only by the novelty of the smell, but also by the changed position of one of the containers or the new sequence of containers in the room. At the same time, rodents with damaged connections between the AON and the hippocampus still did not notice the difference between the new and old environments.

Earlier studies have shown that loss of the ability to distinguish smells may be one of the early symptoms of Alzheimer's disease, and AON is rapidly degraded in the early stages of the disease. The new data can be used to create more effective diagnostic tests.

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Temperature and synthesis of pure polymers 01.10.2020

Florida State University researchers have figured out how temperature during the synthesis process affects the properties of the final polymer. The discovery will help create new environmentally friendly plastics.

Plastics made from petroleum and other non-renewable resources can take centuries or millennia to decompose. All because of the stability of their structure, due to strong bonds between long molecular chains. These bonds, as well as the position of the chains, are formed in the process of synthesis. Therefore, the final properties of the polymer also depend on the synthesis conditions.

Finding the right temperature is key to getting the best materials that can replace inexpensive petroleum-based polymers with economically viable, environmentally friendly materials.

As an object of study, scientists used polyacetals with large internodal distances. This class of polymers is most often used for the production of various kinds of plastics. As a rule, these materials are obtained from environmentally friendly biomass. However, they are durable and break apart more easily in water.

The researchers found that upon rapid cooling, the polyacetals become rigid and crystallize, and their molecules self-assemble into a specific phase, which the scientists called "Form I". When slowly cooled, the material also becomes crystalline, but the resulting crystals have a different structure and scientists call them "form II". If the polymer is cooled at intermediate temperatures, the material does not harden at all. According to the researchers, this phenomenon has never been observed in any other crystalline polymers.

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