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New material for the bone frame

09.02.2018

A diseased organ or tissue can be transplanted by taking a replacement from a donor - however, this is not possible with all organs. This has been done for quite a long time, but recently, doctors and biologists are increasingly trying to grow tissues for transplantation from scratch, right in the laboratory, and there are already absolutely amazing achievements (for example, a boy with epidermolysis bullosa literally grew new skin) .

And you can also do otherwise: to transplant to the patient not a ready-made organ, but a frame on which the body itself will complete the necessary tissues. Such a scaffold must, of course, be biocompatible and at the same time it must stimulate recovery processes. For example, bone scaffolds make it possible to restore the porous three-dimensional structure of damaged bones and their physiological functions, they provide an influx of nutrients to the site of damage, due to which the bone tissue successfully regenerates.

Researchers from the University of Helsinki and the Institute for Theoretical and Experimental Biophysics (ITEB) of the Russian Academy of Sciences have found a new, more efficient material for the bone scaffold by combining hydroxyapatite, gelatin, polypyrrole and mesoporous silicon oxide. Synthetic hydroxyapatite is widely used in bone tissue engineering - its chemical composition is similar to bone hydroxyapatite. However, despite its biocompatibility and the ability to stimulate bone regeneration, it has a strong drawback - it is too fragile. On the other hand, in the company of other compounds, it becomes stronger.

Another component of the new scaffold, silicon dioxide, is also able to activate bone mineralization; in addition, it can be used as a drug delivery vehicle and regulate the release of drugs at the right place with its help. The third component is gelatin: osteoblast cells are well associated with it, due to which bones grow. Finally, polypyrrole is needed to bind together hydroxyapatite, gelatin and silicon dioxide. It also has its drawbacks, but in combination with other materials it is quite possible to use it without fear that it will damage living bone tissue.

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TCB010FNG - Automotive Power Management ICs 13.06.2017

Toshiba Electronics Europe (TEE) announced the release of a new system regulator IC designed to meet the growing power requirements of car audio systems. The TCB010FNG is a complete solution that integrates the required power supply and all basic troubleshooting and diagnostic functions, Toshiba told CNews.

The TCB010FNG contains a multi-line microcontroller power supply that maintains power during small interruptions in battery power. For added flexibility, the device also includes multiple regulated power supplies and a fixed voltage power supply.

In addition to the 2-channel high-side switch, the IC also contains a number of monitoring functions, including battery voltage, auxiliary supply voltage, and microcontroller output voltage, each of which can be set to a threshold value.

Because the IC uses series regulators, users can build devices without worrying about electromagnetic interference, Toshiba said.

TCB010FNG is available in P-HSSOP36-1116-0.65 package. Deliveries of introductory samples begin now, and the start of mass production is scheduled for June this year.

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