The ovary was printed on a 3D printer. Free Technical Library News

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The ovary was printed on a 3D printer

23.05.2017

Modern medicine is increasingly mastering the method of three-dimensional printing. It is possible to print an ovary on a 3D printer, which, after being transplanted into the body of a female, will work like a real one.

Researchers from Northwestern University (USA) did not print the entire ovary - after all, it is a rather complex, multicomponent organ. As you know, in the ovaries, the maturation of eggs occurs, which are located in special structures - follicles. The follicles themselves are immersed in connective tissue.

Monica M. Laronda and her colleagues XNUMXD printed the connective tissue base of the ovary: the printer was charged with gelatin, which was obtained from collagen, one of the main proteins of connective tissue - collagen was in the form in which it is usually present in the ovaries of animals . Then, mouse follicles with eggs inside were immersed in the resulting (printed) gelatin base.

The point was to test how different stacking of gelatin fibers would affect the viability of the egg follicles. The fibers were laid in layers at different angles to each other, so that different variants of the gelatin base with different porosity were obtained.

In the most successful version, the egg remained alive for eight days - and it was these semi-artificial ovaries that were transplanted into seven mice to replace their own. Once transplanted, the blood vessels penetrated the gelatinous base, supplying the follicles with nutrients and hormones, so that the eggs eventually went through all the necessary stages of development and became ready for fertilization. And, when males were provided to experimental female mice, three of them became pregnant and gave birth to completely healthy offspring - that is, the follicles, which themselves produce the hormones necessary for reproduction, worked as they should in these females.

Perhaps in the future, with the help of such ovaries, it will be possible to get rid of some forms of infertility; True, semi-artificial ovaries will need to be scaled to fit a person and make sure that the blood vessels can fully provide them with everything they need in the female body.

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