Antibiotics speed up the growth of bacteria. Free Technical Library News

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Antibiotics speed up bacterial growth

07.02.2017

We know that antibiotics work against bacteria, but it often happens that bacteria adapt to antibiotics. And then biologists and physicians have to look for new substances that would act on bacteria. When looking for such substances, it is extremely useful to know how drug resistance generally manifests itself, how it develops and what it depends on.

We know that antibiotics work against bacteria, but it often happens that bacteria adapt to antibiotics. And then biologists and physicians have to look for new substances that would act on bacteria. It is extremely useful to know how drug resistance manifests itself in general, how it develops and what it depends on.

Researchers at the University of Exeter experimented with E. coli and the tetracycline antibiotic doxycycline, which inhibit protein synthesis in bacterial cells. E. coli after doxycycline treatment became resistant to the antibiotic, as expected, but in addition, the bacteria began to grow faster, and as a result their colonies turned out to be three times larger than those of bacteria that did not taste doxycycline. The ability for accelerated growth was also preserved after the antibiotic was removed from the nutrient medium.

When bacteria grow on a solid substrate, they form so-called biofilms, in which bacterial cells are immersed in a special intercellular substance - a matrix. The biofilm adheres very strongly to the surface of the substrate and is very resistant to physical and chemical influences. Molecules of the biofilm matrix are released from the collapsing cells, so that, by self-destructing, the bacteria help the growth of the colony.

E. coli were grown in a liquid medium, where it was simply impossible to form a biofilm. But, having got rid of the viral genes of self-destruction, the bacteria increased the "fertility": after all, if the cell does not die, it will begin to divide and increase the size of the colony - which is especially timely when a dangerous antibiotic is floating around.

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