A human liver has been grown in the head of a mouse. Free Technical Library News

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Human liver grown in mouse head

05.07.2012

The scientists implanted liver tissue made from human skin stem cells into the head of a mouse and grew a tiny organ that already performs many of the functions of the liver. Scientists at the University of Yokohama have grown a tiny human liver inside a mouse. It remains to be seen whether the grown organ can perform all the functions of the liver, but if so, then medicine will have huge opportunities for unlimited production of donor organs.

In their work, the researchers used induced pluripotent stem cells from human skin, which developed into hepatic tissue progenitor cells. The scientists then added two more cell types - mesenchymal cells and vascular endothelial cells. As a result, without any scaffolding and scaffolding, the cells independently formed normal liver tissue about 5 millimeters in size. This tissue was then implanted into the head of a mouse, and the rodent was able to absorb some of the drugs that only the human liver can handle.

Thus, for the first time, it was possible to create a functional organ with a vascular system from stem cells, which opens up great prospects in transplantology. The cultured liver tissue was transplanted into the head of the mouse so that increased blood flow in this area could stimulate accelerated liver growth. Within just 48 hours, the tiny liver began to form human blood vessels and produce human proteins. The levels of glycogen and amino acids in the tissues were the same as those found in the human liver.

So far, the grown liver is not a perfect copy of the human one. Some "details" are missing, such as the bile ducts. It is also necessary to solve the problem of forming a large body of the correct form.

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