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Growing liver directly in the human body

07.04.2024

Liver transplantation has become an integral part of medical practice for the treatment of severe diseases of this organ. However, the shortage of donor organs and complications associated with surgery create a need for alternative treatment methods. In this context, LyGenesis has introduced an innovative approach to restoring liver function based on the use of the patient's own cells.

American biotechnology company LyGenesis, based in Pittsburgh, Pennsylvania, has launched clinical trials of its cell therapy. The first patient with acute liver failure had donor cells injected into a lymph node in the upper abdomen.

The shortage of donor organs for transplantation is a pressing issue both in the United States and around the world. Waiting for a suitable organ can lead to tragic consequences, and alternative treatments are becoming increasingly necessary. The method proposed by LyGenesis aims to create miniature organs in lymph nodes using donor cells.

One of the main advantages of this therapy is the ability to use one donor organ to treat several patients. In addition, this approach allows the use of tissues that were previously considered unsuitable for transplantation.

After successful experiments on animals, the company moved on to clinical trials on humans. The first patient has already been discharged from the hospital and continues to receive the necessary medications under the supervision of doctors. The cells will begin to multiply in the lymph node, forming a structure that can perform the functions of the liver.

According to LyGenesis CEO Michael Hufford, the new liver will be highly vascularized, allowing it to effectively filter blood and maintain vital functions.

Cell therapy offered by LyGenesis represents a revolutionary approach to the treatment of liver failure. If successful, this method will not only reduce the wait for a liver transplant, but will also significantly improve treatment outcomes for many patients facing this difficult problem.

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