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Biological time can be determined by a blood test
22.09.2018
It is known that many diseases behave differently at different times of the day - for example, in the male body, the consequences of a heart attack will be more serious if an attack occurs during sleep; also, drugs and medical procedures act differently depending on what "internal hour" they fall on (in particular, a year ago we wrote that some heart surgeries are best done in the middle of the day). So it would be very good if we had a way to accurately enough, quickly and easily determine our biological time.
It is known that many genes obey the biological clock. The activity of a gene can be determined by the level of messenger RNA that is copied from it - as we know, RNA molecules serve as an intermediary, a carrier of genetic information from DNA to molecular machines that synthesize proteins. Researchers from Northwestern University (Chicago) have selected forty out of thousands and thousands of human genes that are most convenient to use to assess biological rhythms - that is, they leave fairly noticeable traces in the blood in the form of RNA, and their activity is strongly subordinated to daily rhythms.
The method was tested on eleven volunteers, and it turned out that it allows you to guess the internal time with an accuracy of two hours. Of course, before there were attempts to determine the time of the circadian rhythm by blood, but in other methods, many samples were taken for this.
In the new method, only two blood samples per day are sufficient. The authors of the work claim that their analysis allows taking into account individual characteristics in the activity of genes, and therefore it can be used with any person.