Can people with Parkinson's disease who can't walk anymore ride a bike? Detailed answer

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Can people with Parkinson's disease who can't walk anymore ride a bike? Detailed answer

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Can people with Parkinson's disease who can't walk anymore ride a bike?

Parkinson's disease is characterized by impaired motor activity to the point that a person has difficulty taking steps and quickly loses balance, falling to the ground. However, at the same time, some of these patients ride a bicycle without difficulty, no different from healthy cyclists. This phenomenon is called paradoxical kinesia and is still poorly understood, however, in practice, cycling therapy is successfully used to alleviate the symptoms of the disease.

Authors: Jimmy Wales, Larry Sanger

Random interesting fact from the Great Encyclopedia:

Which football player was prevented from making an excellent career by the anticipation of the end of the world?

Argentine goalkeeper Carlos Roa, who played for the Spanish "Mallorca", at the peak of his career, announced his retirement, although he was interested in Chelsea and Manchester United. He explained his decision by the fact that he was waiting for the end of the world, which was to come along with the third millennium. After he returned to football, but played only in teams of the lower divisions.

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Breakthrough in limb regeneration 09.03.2019

Scientists from Tufts University (USA) have uncovered the genetic mechanisms that explain why blocking electrical signals in the body of flatworms sometimes leads to the fact that they grow an extra head instead of a tail. Their study will help restore people's ability to regenerate limbs.

Three years ago, scientists found that the process of head regeneration in planarian worms is controlled not only by genes, but also by electrical signals exchanged between the cells of these invertebrates when growing a lost tail or front part of the body.

By studying this process, the team learned to make the worms grow alien heads with a completely different brain architecture, using electrical signals recorded from observing the head growth of other planarian species.

Subsequently, scientists tried to go further and decided to grow a worm with two heads and no tail. A year ago, they managed to solve this problem by cutting several dozen planarians into three parts, separating their heads and tails, and treating these “stumps” with octanol alcohol, which blocks the transmission of electrical signals between cells.

The successful completion of these experiments made us think about what plays the primary role in this process - electrical signals or genes. It is quite possible that the former may not orchestrate regeneration, but simply reflect changes in the activity of those DNA regions that are responsible for restoring a lost tail or head.

To answer this question, scientists conducted another series of similar experiments. They cut several planarians into pieces and watched how the activity level of certain genes associated with tail and head growth "programs" changed in the first hours after the operation. In parallel, they observed fluctuations in the electrical potential of cells located at the edge of the wound.

As it turned out, differences in the voltage on cell membranes in different parts of the wound appeared long before the level of activity of the Wnt, notum, and other DNA regions that are directly responsible for the formation of new organs and limbs changed. This suggests that it was the electrical signals that "conducted" the genes, and not vice versa.

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