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3D printing inside the human body

20.06.2020

More and more work in our time is focused on the creation of human organs using 3D printing. However, such body parts must be implanted through relatively large incisions. New bio-ink technology will allow "growing" organs inside the human body.

There are already different types of bio-inks in the world. As a rule, it is a liquid containing living cells, scaffold material and growth factors that encourage cells to multiply on the scaffold material, gradually turning it into a biological tissue.

Such bio-ink is "squeezed out" from the nozzle of a 3D printer, creating organs outside the body, layer by layer. In many cases, they harden under the influence of ultraviolet radiation. Unfortunately, these rays are harmful to the patient's tissues. The new bio-ink developed by American scientists works differently.

Fluid is delivered from a thin tip of a robotic nozzle that is surgically inserted into the patient's body through a small incision. To hold each strand of bio-ink in place, the nozzle makes a small niche in the patient's soft tissues and then places a clot of fluid into this space, which serves as an anchor. When the nozzle is removed, it places another anchor on the outside of the fabric. The scientists also say it's important to note that such a material does not require UV radiation in order to harden.

Researchers believe that in the future this substance can be used to create parts of the body such as blood vessels or spinal discs. However, now the material can be used as a "plaster" for damaged or defective organs.

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Random news from the Archive

Metal nanowire network with brain-like features 30.12.2019

An international collaborative research team led by the National Institute of Materials Science (Japan) has succeeded in creating a neuromorphic network composed of numerous metallic nanowires. Using this network, the team was able to create electrical characteristics similar to those associated with higher-order brain functions unique to humans, such as remembering, learning, forgetting, becoming alert, and returning to calm. The team then figured out the mechanisms that triggered these electrical characteristics.

The development of artificial intelligence (AI) techniques in recent years has advanced rapidly and has begun to influence our lives in various ways. Although AI processes information in a similar way to the human brain, the mechanisms by which the human brain works are still largely unknown. The main components of the brain, such as neurons and the connections between them (synapses), have been studied in detail. However, many questions regarding the brain as a whole, consisting of many components, still await answers. For example, we still do not fully understand how the brain performs functions such as remembering, learning, and forgetting, and how it becomes alert and returns to calm. In addition, living brains are difficult to manipulate in experimental studies. For these reasons, the brain remains a "mysterious organ." In the framework of the development of brain sciences, another approach to the study of this organ is effective - in which materials and systems are created that are capable of performing functions similar to those of the brain, and their mechanisms are analyzed.

A collaborative research team recently created a complex brain-like network by integrating numerous silver (Ag) nanowires coated with a polymer (PVP) insulating layer about 1 nanometer thick. The connection between the two nanowires forms a variable resistive element (i.e., a synaptic element) that behaves like a neuronal synapse.

This network of nanowires, which contains a large number of complexly interacting synaptic elements, forms a "neuromorphic network". When voltage was applied to the neuromorphic network, it seemed to be "struggling" to find optimal current paths (i.e., the most electrically efficient paths). The research team measured the processes of forming, holding and deactivating the current path while the electrical current flowed through the network and found that these processes always fluctuate as they progress, similar to the processes of remembering, learning and forgetting the human brain.

The observed temporal fluctuations also resemble processes in which the brain becomes alert or returns to calm. Brain-like functions mimicked by the neuromorphic network are found to occur as the vast number of synaptic elements in the network work together to optimize current transfer through self-organizing and emergent dynamic processes.

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