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stem cell management

12.02.2020

A team of microbiologists from the University of Edinburgh has done a rather interesting experiment to turn off one important mechanism in stem cells - namely, to deactivate a regulatory molecule that controls the cell's immune defense impulse when it is threatened. The results of the study, being very positive, promise to soon become the basis on which even more effective and interesting experiments will be carried out.

Unlike any other cells in the body, stem cells do not have their own defense system and cannot use an immune impulse for this protection - on the other hand, when some viruses interact, they still send this impulse, which somewhat complicates the work with stem cells, because in this way it becomes difficult to modify them in the laboratory.

That is why Scottish specialists conducted research, according to which they discovered a special protein called MAVS, which in turn triggers an activation impulse of the miR-673 regulatory molecule. And this molecule, in turn, activates the immune defense of the stem cell, preventing it from being manipulated as scientists need. After conducting several sessions of experiments and observations on embryonic stem cells belonging to mice, scientists found that the removal of this regulatory molecule leads to a significant simplification of work with the cell itself.

In other words, by deactivating this molecule, specialists can more easily manipulate cells, thus changing their structure and chemical composition much faster and easier. And this, in turn, leads to much more efficient results when remaking a stem cell into something else. However, it remains to wait for new results.

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