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Miniature neural networks of the brain are grown

09.07.2019

Researchers from Japan have obtained functional neural networks from cerebral organelles. Although organoids cannot actually "think", these networks can be used as a model for studying brain function and the development of neurological diseases.

Cerebral organoids are artificially grown three-dimensional tissue cultures that resemble the human brain and can mimic its development. To get them, scientists have created a "ball" of pluripotent stem cells that can develop into various tissues of the body. They then placed the cells in a petri dish filled with nutrient material that mimicked the environment needed for brain development. Using organoids, the team successfully visualized synchronized and unsynchronized actions throughout the neural network and in the connections between individual neurons.

The researchers also developed a tool to assess the complex dynamic change in network activity in the detected area. He allowed to track the activity of more than 1000 cells. The new method could help scientists understand the processes by which information is encoded in the brain through the activity of certain cell types, as well as the fundamental mechanisms that underlie mental illness.

As the first author of the study, Jun Takahashi, a professor at Kyoto University, noted, applied research on organoids will find applications in three main areas in the future: drug discovery, modeling neuropsychiatric disorders, and regenerative medicine.

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