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Smart medicine with artificial DNA

02.07.2019

The ability to gradually introduce the necessary substances into the patient's body to treat a particular disease is not as simple as it might seem at first glance - even if we are talking about the use of so-called ointments that can constantly release the necessary substances under the skin.

Precisely with the aim of creating a conceptually new type of such a smart drug that can independently and, most importantly, a follower, release the necessary substances and groups of substances into the human body, a team of researchers from the Technical University of Munich presented their new study on the development of such a drug concept, which has already demonstrated really high level of efficiency.

The new smart drugs are based on the use of two main components - a specially created hydrogel and an edited segment of artificial DNA, which serves as a retainer of the substances stored in it. The hydrogel itself forms a certain format of such a drug, inside which various substances are released on a sequential basis. As an experiment, scientists used silver, copper oxide and gold nanoparticles, and it was in this sequence that they were isolated.

Thanks to external editing of the behavior of artificial DNA - inside which these nanoparticles were enclosed - scientists were able to correctly set up the trigger reaction of DNA, which, as it degraded and decreased, gradually released these nanoparticles from the hydrogel. Preliminary results of the study showed that scientists actually managed to create a conceptually new and, most importantly, an effective way of such a release of substances.

So very soon, a team of researchers will start testing their development on experimental mice - because their biology is largely similar to that of humans. Although, of course, at this point in time there are quite a few questions and moments related to the implementation of this development on a larger scale - and this will depend on how it will generally take root in the world.

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