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Fugu fish poison cure

29.06.2019

Scientists at Harvard University have presented a new painkiller based on the poison of puffer fish. This fish belongs to the family of pufferfish, and is the carrier of the strongest poison - tetrodotoxin. The tool has already been successfully tested on rodents. It worked great and was not addictive, unlike opioid painkillers, according to the school's website.

Tetrodotoxin is a paralytic poison, meaning it attacks nerve tissue and eventually paralyzes the victim. It is found in the spines of the puffer fish, whose liver and gonads are deadly poisonous.

Nervous tissue is responsible for our pain sensations, and studies have shown that in small doses, tetrodotoxin can block signals from nervous tissue without damaging it. In addition, tetrodotoxin is not addictive.

Thus, the functioning of some voltage-sensitive sodium channels in some cases entails the occurrence of chronic pain. Tetrodotoxin, on the other hand, has a very high affinity for these channels, blocking, like a plug, the flow of ions through the channel and blocking nerve transmission.

Therefore, people suffering from chronic pain can take it without fear of becoming addicted to it for the rest of their lives. A tetrodotoxin-based drug called Tectin is currently in Phase XNUMX research, a phase prior to FDA approval.

Doctors are confident that tektin can help cancer patients who are no longer affected by other painkillers. If all trials of the drug are successful, the new analgesic will appear on the market within the next three years.

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