Ideal vascular prostheses. Free Technical Library News

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Ideal vascular prostheses

08.04.2019

Scientists from Yale and Duke University (USA) have developed acellular human vessels, very close to the "real" blood "highways" of people prostheses.

Blood vessel transplantation is an extremely complex procedure, even with the current level of medical technology. Most often, doctors have to take them from other parts of the patient's body and transplant them into more important damaged organs. In some cases, vascular transplantation from animals is used. An alternative is artificial prostheses, which are made of polymers and implanted into the gap. However, all these methods almost always fail, and the patient begins to reject the implant.

The new technology uses a radically new approach. Scientists took from the bodies donated to science, samples of endothelial cells that form blood vessels and mucous membranes. These cells were placed on a specially prepared mesh frame made of biodegradable material. As a result, protein tubes formed by growing cultures grew.

After the removal of live cells, artificial vessels were obtained ready for transplantation. Removal of the live culture is necessary to optimize industrial production, ease of storage, and eliminate the likelihood of a patient's immune response. In the future, such tube blanks can be mass-produced and delivered to medical institutions, where they will be stored for a long time in anticipation of an operation.

The study was conducted on 60 patients from 18 to 80 years old, who were followed up from 16 to 200 weeks after transplantation. The organisms of the test subjects accepted the implants and grew multi-layered living tissue around them. Even if the new artificial vessel was damaged, it healed with the patient's cells.

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