Nanotablets with a micromotor. Free Technical Library News

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Nanotablets with micromotor

16.09.2018

Self-propelled particles release the active ingredient of the drug directly in the stomach, interact with hydrochloric acid, and move under the influence of the resulting hydrogen.

The idea to create "moving" pills that will act in a specific organ was born a long time ago. A few years ago, scientists created microparticles of magnesium and zinc for medicinal purposes, but they could only be injected.

A group of scientists at the University of California at San Diego, led by Joseph Wang, have been working for several years to create micromotors for tablets that could be taken orally. Recently, scientists have made a major breakthrough in their work: they have developed micromotors for tablets that freely reach the fundus of the stomach, and are activated after contact with hydrochloric acid. Their spherical micromotors, consisting of a magnesium core and coated with a layer of acid-sensitive titanium dioxide, do not exceed 20 micrometers in size. The surface layer of the particles is coated with a 100-nm layer of chitosan, which ensures the attachment of the nanotablet to the stomach wall. The magnesium core in the free area can interact with hydrochloric acid. Protects the entire system shell of a mixture of maltose and lactose.

Micromotorized nanotablets have already been successfully tested with fluorescent dyes in lab rats, which have helped track drug release.

However, the use of such micromotors is difficult due to a number of important problems, for example, the impossibility of their mass production.

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