Weak immune memory makes bacteria stronger. Free Technical Library News

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Weak immune memory makes bacteria stronger

18.03.2018

Scientists from Virginia Tech, along with colleagues from the University of California at San Diego and a number of other research centers, have found that partial resistance helps disease-causing microbes become much stronger than if there were no resistance at all.

Experts studied with small birds - Mexican lentils, suffering from conjunctivitis, which is caused by mycoplasma bacteria. This disease is quite dangerous, and can bring the bird to blindness. Moreover, conjunctivitis mycoplasmas, as usual, have more dangerous strains and less dangerous strains, which, once in the bird's body, cause more or less complete resistance.

Different strains are constantly present in the environment and constantly compete with each other for hosts. Let's imagine that a strong strain has reached some bird population, which has not yet encountered a disease and which has no resistance. It will, of course, infect most individuals; and if any weak strain comes next, only some of the birds will be left to his lot.

But what if it happened that the population in the past was completely ill with a weak bacterium? In this case, most individuals have partial stability. And then if another wave of infection comes to the birds, then not just strong, but very strong strains will get an advantage - those that can bypass partially trained immunity. And then these "super strains" will dominate in the next generations of bacteria.

Experiments with bacteria and mathematical models based on the results of experiments suggest that weak immune resistance makes bacteria literally twice as cool - that is, those varieties that are twice as strong, twice as virulent as ordinary strong strains, get an advantage.

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