One of the reasons for poor appetite. Free Technical Library News

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One of the causes of poor appetite

12.11.2017

People who always do not want to eat turned out to be a bit of mutants.

A decrease in the concentration of the hormone asprosin, which is responsible for the level of glucose in the blood, helps to reduce the feeling of hunger and reduce the amount of food consumed by a person, American scientists have found.

During the experiment, scientists from the Baylor College of Medicine found that some patients with abnormally poor appetite have a mutation in the FBN1 gene. It turned out that this group of people lacks a small fragment of the protein from which asprosin is formed in the body of a healthy person.

Further study of the hormone's action showed that the compound interacts with neurons in the hypothalamus. According to the study, asprosin has different effects on two types of nerve cells - appetite-stimulating AgRP neurons and appetite-suppressing POMC neurons. As a result, the hormone increases the feeling of hunger, causing the body to demand more food.

In addition, scientists have found that overweight people have high blood levels of asprosin. The researchers note that they have already developed a tool that completely neutralizes the effect of the hormone, and also conducted the first clinical trials.

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