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Artificial skin for diabetes treatment

08.08.2017

Skin grafts made using CRISPR gene-editing technology prevent mice from developing diabetes, and scientists say these properties of artificial skin could also be useful in humans.

In a proof-of-concept study, scientists at the University of Chicago edited neonatal mouse stem cells to control the production of glucagon-like peptide 1 (GLP-1). This hormone stimulates the synthesis of insulin by the pancreas while maintaining the required level of glucose in the blood. The genetically modified skin grafts were then transplanted into mice fed a high-fat diet to induce obesity. These mice reversed insulin resistance and were half the weight of mice without skin grafts.

Obesity is one of the major risk factors that can cause type 2 diabetes with high insulin resistance. According to the head of the study, artificial human skin made from stem cells could be used to treat people with the disease.

Artificial skin has been used to treat burn patients for decades. But as technology has advanced to the point where it is now possible to grow skin in the lab, researchers have turned to finding ways to use it to treat other diseases. The researchers say they now have the ability to explore the use of various modified gene transplants to treat various diseases.

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