Tanning without ultraviolet radiation. Free Technical Library News

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Sunburn without UV

25.06.2017

A tan appears because ultraviolet stimulates the synthesis of melanin, a dark-colored pigment that must absorb ultraviolet radiation, preventing it from penetrating deeper and harming the deeper layers of the skin. But the skin will still receive some harm: the DNA in the cells will be damaged, and it remains only to hope for molecular repair enzymes that will correct these damages and prevent cell death or, even worse, the transformation of cells into cancerous ones.

However, life is simply not sweet for many without a tan, and they still go out into the sun again and again or go to the solarium. Is it possible to get tanned skin without being exposed to dangerous ultraviolet radiation? Researchers at the Massachusetts General Hospital and the Dana and Farber Cancer Institute say it is possible.

A few years ago, experts experimented with mice that were unable to synthesize melanin - such animals had a mutation in the genome that turned off pigment synthesis. But at the same time, it was found that a substance called forskolin could trigger the synthesis of melanin, bypassing the mutation, so that there was enough melanin to protect mice from the unpleasant effects of ultraviolet radiation.

However, at the same time it turned out that forskolin is useless for humans: compared to mice, our skin is thicker, and the substance simply does not penetrate to a sufficient depth. However, the researchers were able to find another compound - more specifically, a whole class of compounds that are similar in action to forskolin and that are effective on human skin. Cells have special enzymes, abbreviated as SIK, on which the activity of genes that control melanin synthesis depends. Scientists have studied molecules that inhibit the activity of SIK proteins, thereby activating pigment synthesis. The specific molecular mechanism is different than with forskolin, but the end result is the same: a UV-free tan.

Before any drugs with "tanning molecules" appear on the market, you need to make sure that they will not have any oncological and generally any harmful effects.

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All devices support the DC-HSPA+ 3G standard with reception speeds up to 42 Mbps and are equipped with a slot for microSD cards, Wi-Fi 802.11b/g/n and Bluetooth 4.0 modules, as well as a microUSB port.

Measuring 4 x 124,4 x 61,4mm and weighing 11,2g, the Zenfone 115 features a 4" multi-touch TN display with 800 x 480 WVGA resolution and is powered by the Intel Atom Z2520 dual-core processor clocked at 1,2 .1 GHz, has 5 GB of RAM and has a 1170-megapixel rear camera, which is complemented by a front-facing VGA camera. The possibility of battery life provides a removable rechargeable battery with a capacity of XNUMX mAh.

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As for the Zenfone 6 phablet, it is also based on a dual-core 2580 GHz Intel Atom Z2 processor, but boasts a 6-inch IPS screen with HD resolution of 1280 x 720 pixels, which is friendly with GloveTouch and pentouch. There is also a 13-megapixel rear camera with PixelMaster technology and f / 2,0 aperture, an audio subsystem with SonicMaster technology for improved sound quality and a built-in 3240 mAh rechargeable battery. In addition, depending on the modification, there are 1 or 2 GB of RAM and 8 or 16 GB of internal flash memory on board. At the same time, the dimensions of the “tablet phone” are 166,9 x 84,3 x 9,9 mm, and its weight is 200 g.

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