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Gut microflora affects our health and mood

12.01.2017

Physiologists from the Universities of Zaragoza (Spain) and Exeter (UK), led by Professor Jose E Mesonero, have discovered the mechanism by which the intestinal microflora affects our health and mood.

Experimenting first in cultured cells and then in mice, the authors found that the TLR2 protein, an important gut health detector, regulates serotonin levels. This "feel good hormone" is a neurotransmitter that delivers signals to the brain and simultaneously controls bowel contractions.

This discovery allows us to better understand the complex influence that the gut microflora has on a wide variety of aspects of our physiology. For example, TLR2 dysfunction has previously been shown to lead to severe intestinal inflammation. Effective cures may now be found for this and other diseases.

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