Development of antibiotic resistance. Free Technical Library News

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Development of antibiotic resistance

04.01.2017

Bacteria can survive treatment with antibiotics if there are enough resistant cells around them that produce special factors that resist treatment. This is a new look at how the microbial environment can resist antibiotics.

The study was conducted using slow-motion microscopy, tested in computer simulations and in mice. "Working with mice, we have seen that antibiotic-susceptible Streptococcus pneumoniae bacteria are not killed by chloramphenicol treatment, but animals are infected with resistant bacteria," Robin Sorg, a microbiologist at the University of Groningen, said in a statement.

This showed that resistance genes were being transferred. Moreover, the data obtained are confirmed by the facts known from clinical practice that antibiotic-susceptible bacteria sometimes come from patients who have not been helped by antibiotic treatment. Now it is clear why this is happening.

It turned out that susceptible bacteria can survive in the presence of resistant bacteria, which can eventually crowd them out. "We know that the use of antibiotics plays into the hands of selection for resistance. But we don't fully understand this process and why antibiotic resistance can develop so quickly. Single-cell studies will help unravel these questions," Sorg said.

According to the author of the work, the whole point is that cells susceptible to antibiotics only stop growing, but do not die. Many antibiotics use the mechanism of cell division or actively metabolizing cells. These cells have time to take resistance genes from the environment. Sorg believes that if personalized medicine is used, then it is necessary to check the patient for the presence of resistant, but non-pathogenic microbes, before prescribing antibiotics. Such microbes increase the risk of transmitting pathogens to them.

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