With age, wounds heal more and more slowly. Free Technical Library News

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Wounds heal more slowly with age.

01.12.2016

Scientists from the Rockefeller University (USA), led by Professor Elaine Fuchs, figured out why wounds begin to heal more slowly with age.

The researchers performed experiments on the skin of mice between the ages of two months and two years. For a human, this is equivalent to a spread of 20 to 70 years.

The healing of wounds on the surface of the body is a complex process in which different types of cells are involved. To put it very simply, at a key stage, keratinocytes (skin cells) migrate to the edges of the wound, so that it gradually heals. This process must be constantly coordinated with the cells of the immune system, which ensures that no infection or any foreign substance enters the body through the wound.

This coordination occurs at the biochemical level and, as it turned out, begins to work worse over time. "Our experiments have shown that as we age, interference in communication between skin cells and immune cells slows down wound healing," Professor Fuchs explained.

This discovery in the future may allow the development of medical agents that accelerate skin regeneration in the elderly. "It may be possible to activate pathways that help skin cells communicate better with neighboring immune cells and increase signals that normally decline with age," said the study leader.

The process of regeneration of living tissues is in the center of attention of scientists, and many interesting discoveries have been made in this area recently. For example, it has been established that the early development of the brain and regeneration are regulated by the same mechanism, and the ability of the heart to regenerate is associated with the length of telomeres (the ends of chromosomes that shorten with age).

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