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Anti-inflammatory drugs help with depression

26.10.2016

It is often said that depression and inflammation are interrelated, that one reinforces the other. But in this case, probably, anti-inflammatory drugs should reduce the symptoms of depression.

Indeed, they do work, but not all. According to the results of the work of researchers from Cambridge, ordinary ibuprofen, for example, will not help here. Inflammation is a highly complex immune response involving many different cells and molecules, including lipids called prostaglandins and proteins called cytokines. The anti-inflammatory properties of ibuprofen lie in the fact that it inhibits the synthesis of prostaglandins, however, in order to reduce not only inflammation, but also depression, it is necessary to act through cytokines.

The authors analyzed the results of several clinical studies involving more than 2 people treated for various autoimmune disorders. Inflammation, generally speaking, turns on during infection, when something foreign invades the body; however, it happens that the immune system begins to perceive the body's own cells as foreign, so that as a result, organs and tissues are filled with inflammatory signaling molecules synthesized for absolutely no reason.

In autoimmune disorders, they try to suppress such false signals, reduce their strength, which means to reduce the level of the notorious cytokines. In those clinical studies, the goal of the doctors was specifically immune problems, but at the same time during therapy, the general condition of patients was also recorded. Some were given real anti-cytokine drugs, some were given a placebo, and it turned out that those who took the real drugs had markedly reduced symptoms of depression. What's more, anti-inflammatory drugs often helped primarily against depression, while autoimmune symptoms remained unchanged.

It is known from medical practice that conventional antidepressants are the worst at helping those with elevated levels of cytokines, so anti-inflammatory drugs that act on these signaling proteins could save the situation in such cases. However, before letting them into the clinic, it is necessary to conduct special studies to evaluate the antidepressant effect of just such drugs.

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According to experts, in the foreseeable future, many manufacturing operations will be subjected to automation, which implies monotonous manual labor, but the big problem for the creators of robots is still their inability to handle flexible materials of arbitrary shape. Siemens engineers have found a way to train robots to sew jeans by treating the fabric with a special compound.

Since 2018, relevant experiments have been carried out by Siemens and Levi's. The problem of automation in this industry escalated in the midst of a pandemic, when interruptions in logistics deprived American consumers of the opportunity to receive clothes in sufficient quantities from countries where core production has traditionally been concentrated in recent years.

Robotic arms are difficult to process fabrics that can have different thicknesses and textures, as well as constantly changing shape in the process. Siemens began its experiments in this area with the creation of robots that can process all types of flexible materials, including the thinnest wires for electronics. Later, the realization came that it makes sense to think about automating the manufacturing process of jeans, since they are made from a fairly dense and rigid fabric. The capacity of the clothing market reaches $1,52 trillion a year, so investments in automation can justify themselves at least in a situation where it is necessary to localize production in countries with a high level of wages for workers.

Siemens has found a partner in the young company Sewbo, which proposes the use of a special impregnation for denim, which temporarily increases the rigidity of the material. This property change makes it possible to simplify the processing of the material by robots. The special composition is washed out without residue during further washing of the jeans. Pants of this type are in any case washed during the production process, so the technology becomes slightly more complicated.

The implementation of such solutions also has a social aspect, which in the case of clothing production will be difficult to level. Studies have shown that the replacement of workers by robots does not have the best effect on the lives of the former. Participants in tests of robots developed by Siemens confirm that staff dissatisfaction with automation processes was sometimes expressed even with threats of physical violence.

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