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Brain implant and prosthesis restore sense of touch to paralyzed man

22.10.2016

Researchers from the University of Pittsburgh have developed a system that restored the sense of touch to a person with paralysis of the arms and legs. He can sense objects by touching them with his robot arm, which he controls solely with his mind.

Prostheses are getting better every day, but they still can't restore their user's sense of touch. This is a serious problem when you consider how important the sense of touch is to the use of the hands. Without it, it is almost impossible to understand the difference between a piece of cake and a fork, for example. A team led by Robert Gaunt of the University of Pittsburgh has pioneered a system that overcomes this limitation by allowing a 28-year-old paralyzed man to sense objects with a robotic limb.

To make the system work, the scientists implanted small microelectrodes - each the size of a shirt button - into the patient's primary somatosensory cortex, the exact part of the brain that receives all sensory input from the body. Even before the operation, brain scans showed exactly where the processing of signals from each finger and palm takes place.
After the operation, all signals went through the electrodes. With the help of a computer, this allowed the patient to feel touch through the robotic arm. It is important that stimulation of the cerebral cortex produces natural sensations, not just tingling, and the effect of the operation lasts for months. Patient Nathan Copeland correctly identifies objects in 80% of cases and feels pressure, as well as its intensity, but cannot yet understand whether the object is cold or hot in his hand. "Our main goal is to create a system that moves and feels like a real hand," says Gaunt. "There is still a lot of work ahead, but a start has been made."

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Nanotablets with micromotor 16.09.2018

Self-propelled particles release the active ingredient of the drug directly in the stomach, interact with hydrochloric acid, and move under the influence of the resulting hydrogen.

The idea to create "moving" pills that will act in a specific organ was born a long time ago. A few years ago, scientists created microparticles of magnesium and zinc for medicinal purposes, but they could only be injected.

A group of scientists at the University of California at San Diego, led by Joseph Wang, have been working for several years to create micromotors for tablets that could be taken orally. Recently, scientists have made a major breakthrough in their work: they have developed micromotors for tablets that freely reach the fundus of the stomach, and are activated after contact with hydrochloric acid. Their spherical micromotors, consisting of a magnesium core and coated with a layer of acid-sensitive titanium dioxide, do not exceed 20 micrometers in size. The surface layer of the particles is coated with a 100-nm layer of chitosan, which ensures the attachment of the nanotablet to the stomach wall. The magnesium core in the free area can interact with hydrochloric acid. Protects the entire system shell of a mixture of maltose and lactose.

Micromotorized nanotablets have already been successfully tested with fluorescent dyes in lab rats, which have helped track drug release.

However, the use of such micromotors is difficult due to a number of important problems, for example, the impossibility of their mass production.

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