An interesting life improves immunity. Free Technical Library News

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Interesting life improves immunity

06.10.2016

It is known that sometimes environment and lifestyle influence the immune system more than genes. For example, scientists, comparing the state of the immune system in identical and fraternal twins, found that non-hereditary factors overlap hereditary in 3/4 of cases; that is, vaccinations in the past, germs and toxins that once had to fight, diet, and even how much a person took care of his teeth - all this determines the state of the immune system to a much greater extent than the genetic instructions inherited from parents . But after all, non-genetic factors are not limited to toxins, bacteria, diet and bad teeth.

Researchers from Queen Mary University of London found that the activity of T-lymphocytes largely depends on how diverse the environment around the individual is. T-lymphocytes are one of the best known immune cells; it is they who recognize foreign molecules, they kill infected and cancer cells, and they, by the way, regulate the strength of the immune response.

What does "diverse environment" mean? The experiments were carried out on mice that naturally lived in special cages. Usually the mice had nothing but sawdust on the floor of the "apartment" and some other material for the nest. But for some animals, not only were they given a bigger cage, they also piled all sorts of useless rubbish in the form of large wood chips, multi-colored boxes, some kind of fabric tubes; in addition, mice were given useful objects, such as a squirrel wheel, with which they could play. That is, the landscape around the animals was made extremely diverse.

After two weeks of such an interesting life, the immunity of animals changed: when T-cells isolated from them were stimulated with substances that supposedly indicated the invasion of infectious agents, then T-lymphocytes in response synthesized more interleukin-20 and interleukin-17 - signal proteins, on which they depend immune response to infection. In addition, the T cells of mice that lived in a diverse landscape increased the activity of 56 genes, again associated with anti-infective processes and with the regulation of autoimmune processes. That is, life in a diverse environment clearly benefited the immune system.

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