Stem cells for muscle regeneration. Free Technical Library News

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Stem cells for muscle regeneration

22.09.2016

Myodystrophy - hereditary diseases in which degradation of muscle tissue occurs - is incurable at the current stage of development of medicine. Methods of tissue engineering using stem cells give hope that the disease will be defeated in the future. To do this, you need to learn how to grow muscle stem cells, so that later they can be transplanted into the patient and cause the regeneration of his skeletal muscles.

Such cells grow extremely reluctantly in culture, but they readily die during transplantation, giving few muscle cells. Therefore, researchers are looking for a cocktail of substances that would make the reproduction of muscle stem cells reliable. The same question worries those who hope to grow meat products from animal stem cells.

Another attempt was made by Japanese researchers from the National Center for Neurology and Psychiatry in Kodaira, led by Dr. Takeda Shinishi. They treated satellite muscle stem cells with a substance from the group of cytokines, the so-called leukemia inhibitory factor - LIF. And when such cells were planted in an experimental mouse, they gave three times more muscle tissue than in the control (in the photo, the new cells glow brightly).

"To the best of our knowledge, this is the first experience showing the effectiveness of LIF in muscle regeneration," says Dr. Takeda. "However, the mechanism of action of the factor is still unknown."

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