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Some genes wake up after death

06.07.2016

Some genes that are silenced immediately after the birth of an organism become active again immediately after its death, and continue to work in a dead body for several more days.

It may seem strange and even unnatural, but many genes really work in the body even after its death. Forensic experts who study the blood of a corpse or, for example, the liver, have known about such post-mortem activity for a relatively long time, but researchers from the University of Washington, together with colleagues from the University of Alabama and the Max Planck Society, decided to recalculate, if possible, all "post-mortem" genes, and also find out how long they work.

Genetic activity was measured in the bodies of mice and fish Danio rerio, and the gene yield was very large - after life in fish and rodents, as it turned out, more than 1000 genes still function for some time. At first, it was assumed that all of them would soon, that is, after a few hours, fall silent, but everything turned out to be not entirely true: hundreds of genes remained in working order a few days after the death of the "owners" (in mice, such genes worked for another two days, and in fish - as many as four). Moreover, the “otherworldly” genetic activity was not at all manifested in the fact that the genes gradually fell silent: some of them, for example, first accelerated during the day, and only then began to work more and more slowly, and, finally, stopped forever. Such dynamics obviously depends on the energy and other resources that still remain in the dying cell and which can be used for RNA synthesis.

The discovery will be useful to criminologists, who, according to post-mortem genetic activity, could, for example, additionally specify the time of death.

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