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Enabling and disabling gluttony

15.06.2016

It turns out that there is an area in the brain, "turning off" which, you can moderate the desire for everything tasty and pleasant.

Jocelyn M. Richard, leader of the Johns Hopkins University experiment, explains: relationship between external stimulus and craving for food (or drugs).

First, the mice were taught that if they heard a signal and pressed a lever, a portion of sweetened water appeared in the cage. When the mice heard the signal, the scientists monitored the activity of the ventral pallidium, a region of the brain located in the basal ganglia. The response of the neurons in this area to the sound of the syrup was surprisingly strong: the cells began to work at a frantic pace. The stronger the activity, the faster the mice ran to the lever and got the treat.

The scientists then turned off the ventral pallidium neurons using optogenetics. The mice did not stop loving sugar - but they were much calmer, did not run headlong to the lever, and in some cases completely neglected the opportunity to feast.

"Now that it's possible to regulate cravings for food and other pleasures, we can help addicts regulate their appetites," says Jocelyn Richard.

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