With a lack of oxygen, cell aging begins even before birth. Free Technical Library News

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With a lack of oxygen, cell aging begins even before birth.

13.03.2016

Scientists led by Professor Dino Giussani from the University of Cambridge found that the aging process of body cells begins even in the prenatal period of its development. At the same time, it is possible to influence the rate of future aging with the help of antioxidants.

In the study, the researchers measured telomere lengths in the blood vessel cells of adult laboratory rats born to mothers who took and did not take antioxidants during normal or complicated pregnancies. Telomeres are the end sections of chromosomes, the depletion of which is associated with the aging process of the cell. The most common complication during pregnancy is a decrease in the amount of oxygen supplied to the fetus. In the case of humans, the reason for this may be, for example, smoking during pregnancy. To mimic this complication in rats, the researchers placed a group of rats in a room containing 7% less oxygen than normal.

They found that adult rats born to mothers who received less oxygen during pregnancy had shorter telomeres. In addition, they had problems with the inner lining of blood vessels, which means that these individuals had a higher predisposition for the development of cardiovascular diseases. Antioxidant supplements taken by these pregnant women helped reduce the risk of developing heart disease. Those individuals whose mothers received enough oxygen during pregnancy also benefited from these supplements - their telomeres turned out to be longer.

Thus, scientists for the first time came to the conclusion that it is possible to influence the rate of aging of the body already during its intrauterine development, and the supply of oxygen plays the main role in this process, apparently. Although the results are from rats, the researchers believe that similar mechanisms are at work in humans.

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