The circadian cycle gene influences life expectancy. Free Technical Library News

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Circadian cycle gene influences lifespan

11.02.2016

Scientists from the University of Pennsylvania in the US found that the work of a gene that regulates the daily cycle of sleep and wakefulness in mice is also associated with life expectancy. His "off" led to the fact that two-thirds of the mice in the experiment grew old faster and died.

The researchers artificially created mice in which the BMAL1 protein was inactive during adulthood and compared them with another group - mice that were absent from the protein from birth. In both cases, it disrupted the circadian rhythm of the animals - cyclical changes in blood pressure, behavior, and so on. And some of the signs of aging were also common to both groups - cataracts, signs of neurodegeneration. But in some respects, these groups differed. Mice in which the gene was deactivated already in adulthood did not suffer from arthritis, neither the birth rate nor, most importantly, the overall life expectancy in their population changed.

An analysis of gene expression showed that in both cases the work of the genes responsible for the regulation of the circadian rhythm was blocked, but if the protein was absent from birth, the work of many other genes not related to this function was also disrupted.

Thus, scientists came to the conclusion that it is necessary to reconsider the role of the genes responsible for the daily cycle: apparently, they affect life expectancy not so much by themselves, due to the disruption of the cycle and rapid aging, but play a large role at an early age, in the process of development.

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