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migraine on blood test

24.09.2015

It is still not entirely clear where migraines come from: they say that stress, genes, hormones, alcohol, weather, and much more are to blame. Not so long ago, it was noticed that migraine often accompanies being overweight, according to another hypothesis, systematic headaches arise ... due to a small brain. Some experts believe that in each individual case, in order to find out the causes of migraine, it is generally necessary to conduct special diagnostic experiments.

All this, of course, does not contribute to the correct diagnosis: how to understand that a headache in a particular case is a sign of a migraine, and not something else? (Migraine, we recall, is a special neurological disease that is not associated with either a stroke, or trauma, or a tumor, or jumps in arterial or intracranial pressure.) It would be much easier for doctors if it could be determined by biochemical analysis - that is, if migraine would have a clear biomarker. Researchers from Johns Hopkins University believe that there is such a marker - it is a kind of lipid molecules called sphingolipids.

Lee Peterlin (Lee Peterlin) and her colleagues analyzed blood samples taken from several dozen women with episodic migraine (episodic migraine differs from the chronic frequency of attacks - in the episodic version, they occur no more than 14 times a month). It turned out that they had lower levels of ceramide sphingolipids: 6 nanograms per milliliter versus 000 ng/ml in those who did not suffer from migraine. At the same time, women with migraine had more sphingolipids of another variety - sphingomyelins. In general, sphingolipids play an important role in the regulation of energy balance and inflammation. It is quite possible that when they become larger or smaller than expected, a person begins to suffer from headaches, but the authors themselves do not yet claim any causal relationship - additional research is needed here.

Nevertheless, sphingolipids seem to be quite suitable for objective diagnostics: in order to confirm their own results, the authors of the work invited several more women to the laboratory and tried to guess which of them suffered from migraine by the level of lipids in the blood. And everything worked out - it turned out to be possible to identify patients by a blood test. However, before promoting this method to the clinic, it will be necessary to reproduce the results on a larger sample of patients. And at the same time, to clarify how things are with sphingolipids not only in women, but also in men, and not only with episodic, but also with chronic migraine.

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