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Shoes with GPS will tell you the route

06.09.2014

An Indian startup has developed a shoe that has the functions of a navigator. Unusual shoes were invented back in 2011, and at the moment it is used by about 50 people, according to The Times of India.

Lightweight red shoes allow you to determine the location and route using GPS. The owner learns about which direction to move in with the help of a special device that, through vibration, lets the owner know that he needs to change the direction of movement in one direction or another, depending on which slipper is vibrating - left or right.

Unusual shoes are controlled using a special application for a smartphone, which is connected via Bluetooth. A conventional battery is used as a power source. In addition, it is possible to calculate the calories spent by the owner when walking.

The approximate cost of such innovative shoes is 100-150 dollars. Customers are mainly tourists who do not want to get lost on vacation.

According to the creators, their shoes can also benefit visually impaired people and children. In the future, the developers plan to pay more attention not only to the functionality, but also to the appearance of the product.

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Bats' immunity to transmissible viruses explained 02.11.2020

Bats may be reservoirs for many zoonotic viruses, including SARS-CoV, MERS-CoV, Ebola, and most likely SARS-CoV-2. However, the molecular mechanisms by which bats can safely carry human-lethal pathogens have not yet been clear.

Scientists at Duke Noos Medical School in Singapore seem to have found a solution to this puzzle. Researchers have discovered unique strategies in animals to prevent the development of hyperimmune reactions. These strategies protect animals from disease caused by zoonotic viruses.

Biologists analyzed three species of bats - Pteropus alecto, Eonycteris spelaea (cave nectar bat) and Myotis davidii (steppe bat). As a result, researchers have identified mechanisms that reduce the activity of key proteins of the immune system responsible for the development of inflammatory reactions and the immune response. These mechanisms allow bats to carry zoonotic pathogens without harm to their own health and to transmit viruses to other species.

One of the defense mechanisms of the organism of mice is a decrease in the level of caspase-1. This protein triggers a key inflammatory cytokine protein, interleukin-1 beta (IL-1beta). Another mechanism they use inhibits IL-1beta cytokine synthesis through a delicate balance between caspase-1 and IL-1beta levels.

According to the researchers, the suppression of hyperimmune reactions increases life expectancy and prevents age-related degenerative changes in humans. The discovery will help develop new therapeutic strategies to treat human infectious diseases and prevent viral infections.

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