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Bad fat becomes good

10.05.2013

For a long time, scientists have dreamed of turning unwanted white fat cells into brown ones, which help to “shed” excess weight. Scientists at the University of Bonn are one step closer to that goal by discovering a "switch" in mice that stimulates fat burning.

On Earth, a huge number of people suffer from overweight, which is associated with the accumulation of so-called white fat, which retains excess nutrients. Brown fat cells are exactly the opposite: they burn excess energy. Scientists have spent years trying to figure out how to turn unwanted white fat into usable brown fat. The researchers may have found a way to shed extra pounds by simply turning unwanted fat into "good" fat.

Scientists at the University of Bonn have discovered a microRNA 'switch' in mice that is important for the formation of brown fat cells. MicroRNAs are able to very quickly and efficiently regulate gene activity. A specific miRNA 155 inhibits a specific transcription factor that controls brown fat cells. Moreover, the transcription factor works like a switch: when the expression of microRNA is high, the production of brown fat is blocked, and when it is low, on the contrary, the production of brown fat increases and, accordingly, the body loses excess weight.

It turns out that microRNA 155 functions as a brown fat antagonist. Simply put, as long as there is a certain amount of microRNA 155 in the body, the production of brown fat necessary for weight loss is blocked. This, of course, complicates the development of therapy - if it were the other way around, then for weight loss it would be enough to introduce an excess amount of microRNA 155. Nevertheless, scientists believe that they will be able to develop a drug that will reduce the amount of microRNA 155, especially since in overweight people, an increased content of this miRNA was found.

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Smartphone instead of driver's license 15.12.2014

In 2015, Iowa plans to be the first in the US to replace a plastic driver's license with a mobile app on a smartphone, said Paul Trombino, director of the Iowa Department of Transportation. According to The Des Moines Register, he did this during a discussion of the department's budget. The event was attended by Governor Terry Branstad.

Initially, it is planned to spend about $20 to develop the application. Drivers will be able to download it for free.

“Imagine if your license would just be on your phone,” said Paul Trombino. “At the pace we are moving now, we will be the first in the country to issue such a license. Drivers will still be able to use the traditional plastic card, carrying it in their wallet or bag, however, it will no longer be as necessary as it is now.Drivers will be able to present an electronic ID to police officers instead of a plastic one and, in addition, use it at checkpoints at airports in the state.The application will be highly secure.To access it, the user will need to enter a digital code, Trombino added. This will make the app much more secure than regular permissions."

The head of the transport department expects other departments to learn from their experience and eventually issue their own similar digital certificates.

Currently, more than 30 US states allow car drivers to show police electronic insurance on a smartphone instead of a paper version. Iowa is one of those states.

We add that in 2012 the United States became the first state in which self-driving cars were allowed on public roads. The state of Nevada was the first to introduce relevant amendments to the legislation. Florida and California followed suit.

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