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Implant LEDs Control Brain Functions

21.04.2013

Scientists at St. Louis University and the University of Illinois have developed microscopic LEDs thinner than a human hair.

These LEDs can be implanted anywhere on the body using a standard thin medical needle. The essence of the experiment is as follows: first, genetic engineers modified mice using optogenetics technology, that is, they “taught” brain neurons to turn on and off according to a light signal created by a tiny LED. Then, an LED was implanted closer to these neurons. Turning on the LED activates the neurons, and turning it off, on the contrary, deactivates them. In this way, specific brain functions can be controlled.

With the help of a miniature LED and optogenetics, scientists were able to control the reward system: due to the inclusion of certain neurons, dopamine was released, causing a feeling of satisfaction.

The researchers believe that LED implants, which are made on the basis of printed electronics, will be useful in other neurological studies. Today, similar devices are already used to stimulate peripheral nerves, which reduces or completely disables pain. True, until now it was necessary to use thin optical fibers and laser emitters, which limited the possibilities of optogenetics.

Wireless LED implants offer much more flexibility. Moreover, devices with LEDs of several colors are able to activate and control several neural circuits at the same time. In addition to LEDs, tiny sensors can be added to the implants to take readings of temperature and electrical activity in the brain. The new LED technology is arguably one of the most important advances in neuroscience. It will help you better understand what happens to the brain as a result of disorders such as stress, depression and anxiety. In addition, the control of neural networks can effectively treat these conditions, relieve pain and fear.

Pessimists also have a topic for discussion: such a powerful artificial incentive mechanism can turn anyone into a slave, because today the feeling of satisfaction is realized by much more complex things, such as relationships, purchases, domestic comfort, career, power, creative achievements, etc. In a society of "chip" people, such "difficulties" are not needed.

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3D printing of tiny details 29.12.2022

Engineers at the California Institute of Technology (Caltech) have developed a new method of 40D printing with pure metals or alloys, which allows for a resolution of 3 microns, which in some cases exceeds the capabilities of other similar technologies by an order of magnitude. The process, which is something of a symbiosis of chemistry and XNUMXD printing, will make it possible to manufacture parts for tiny MEMS (microelectronic mechanical systems) devices that are widely used in space, transportation, biomedical equipment and many other things.

The traditional 3D printing process consists of laying down material layer by layer. This, in turn, allows the creation of forms that cannot be obtained by traditional machining methods. Industrial metal 3D printing processes use a laser to melt metal powder at a precise point, and the best of these methods can now achieve resolutions of 100 microns.

The problem here is that some of the metals, copper and silver, for example, have such a high thermal conductivity that even with a well-focused laser beam, heat spreads and melts the metal powder around a given point, which reduces the resolution of the printing process.

In the new printing process, instead of pure metals in powder form, the process is carried out in a volume filled with a special hydrogel. This material is a base of flexible polymer chains, the gaps between which are filled with water. Only in this case, this water still contains a high concentration of metal salts, from which the final printed object will consist.

Further, everything happens as with the usual method of laser printing with plastic. The light of ultraviolet lasers focused at a given point causes polymerization, polymer molecules at this point bind to each other and become rigid. And so, sequentially processing the hydrogel layer by layer with a laser, the structure of the future object is formed.

After that, the laser-processed material is subjected to heat treatment at temperatures from 700 to 1100 degrees, depending on the print material. The temperature is chosen so that it is slightly below the melting point of the metal or alloy used, while the hydrogel begins to burn out, and in the places of its polymerization, threads are formed from metal particles that fuse with each other. Moreover, the hydrogel burning process is implemented in such a way that the metal from the non-polymerized areas settles on the already formed metal chains, strengthening and compacting them in this way.

Using this method, the Californian researchers printed various objects from pure copper, nickel, silver, and several types of alloys as a demonstration of the new technology's capabilities. And now a special department of the California Institute of Technology has already registered a company called 3D Architech, which will patent, further improve, commercialize and license new XNUMXD printing technology.

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