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Contraceptive gel for men

09.07.2012

The application of an experimental contraceptive gel containing a combination of two sex hormones (testosterone and progestin) to the skin reduces the sperm count in the ejaculate of 89% of men to very low values.

In the male body, progestins (synthetic analogues of the female sex hormone progesterone) enhance the contraceptive effect of testosterone. In combination, these two hormones suppress the production of other hormones that regulate sperm formation. Earlier versions of male hormonal contraceptive methods based on this hormonal combination involved the use of progestin-containing pills, implants, or injections.

The new contraceptive drug, developed by researchers at the Los Angeles Institute for Biomedical Research, is a gel applied to the skin that contains the male sex hormone testosterone and a newly developed progestin called nonsider. In addition to the ease of use of the gel, its serious advantage lies in the fact that Nestoron does not have androgenic (inherent in male sex hormones) activity, which can have side effects, such as the appearance of acne or changes in the levels of good and bad cholesterol in the blood.

As part of a primary clinical study, researchers randomly divided 99 healthy men into 3 groups, each of which used one of 6 unidentified gels daily for 3 months. The tested preparations were a gel containing 10 mg of testosterone, or the same gel in combination with a gel containing 8 or 12 mg of nestosterone.

56 men adhered to the study protocol for at least 20 weeks. However, only 23% of participants who used testosterone gel, the concentration of sperm dropped to 1 million per milliliter - a level considered to reduce the likelihood of conception to almost zero. The use of the combined gel provided a similar result in 88-89% of men, depending on the dose of progestin. At the same time, the complete absence of spermatozoa was observed in 78% and 69% of participants who used gels containing 8 and 12 mg of progestin, respectively. For the control group, which used only testosterone gel, this figure was only 23%.

The absence of undesirable side reactions when using the experimental gel indicates the advisability of its further testing in clinical trials.

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