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To predict a heart attack, droplets of blood stop

08.04.2012

Scientists from the Institute of Translational Medicine. E. Scripps began testing a new test that can detect an imminent heart attack. A simple test predicts a possible heart attack using a sample of blood and cells that slough off damaged blood vessel walls.

This invention closes a major gap in the diagnosis of cardiac diseases. Today, doctors can detect a heart attack only when it has already happened. Yet each year, tens of thousands of patients, even after stress tests in the doctor's office, face the devastating effects of a life-threatening heart attack a few weeks later.

A heart attack occurs after an atherosclerotic plaque ruptures in an artery. The result is a clot that blocks blood flow to the heart. Thus, damage to the tissues of the heart occurs, often life-threatening for the patient, especially when it comes to rupture of cholesterol plaques. In the latter case, the disease is often asymptomatic, and a heart attack occurs unexpectedly. The new test solves this problem, i.e. know in advance about the increased risk of damage to heart tissue. Now the doctor will be able to find out about damage to the endothelium (a layer of cells on the inner surface of blood vessels) even before the formation of a dangerous blood clot and prevent a heart attack or stroke.

Unfortunately, the new test does not yet allow you to accurately determine when exactly an attack will occur: in a day, two or a week. Therefore, people at high risk will have to be tested regularly. Currently, scientists are discussing the possibility of creating a portable device that can quickly detect circulating endothelial cells that indicate damage to blood vessels.

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Random news from the Archive

Household DNA analysis and pollution level sensor 26.10.2013

Specialists from the Japanese company Hamamatsu Photonics have developed a sensor that allows you to analyze DNA and monitor the level of environmental pollution at home.

To analyze DNA using a new sensor, quite a bit of blood is enough - about as much as a mosquito sucks. As for pollution, the sensor allows you to monitor the level of radiation and particulate matter (PM2.5). The sensor is a photomultiplier that converts the photon flux into an electrical signal and amplifies it. However, it is not made in the form of an electrovacuum device, as usual, but in the form of a microelectromechanical system (MEMS).

A photomultiplier tube is a key element of a fluorometer, a device that allows you to determine the presence of a specific substance in a sample. The sensor operates in the wavelength range from 300 nm (UV) to 850 nm (near IR). In addition, it can measure the intensity of ionizing radiation, for which you need a scintillator - a substance that emits light under the influence of ionizing radiation. Since the number of emitted photons is approximately proportional to the absorbed energy, in order to estimate the radiation intensity, it is enough to obtain the energy spectrum of the light radiation of the scintillator, which the sensor does an excellent job of.

An idea of ​​​​the dimensions of the sensor, which the developers called Micro PMT, is given by an illustration. For comparison: miniature photomultipliers currently produced are cylinders 1,5 cm in diameter and 5 cm high. Another advantage of Micro PMT is its immunity to vibration and shock, which allows the sensor to be used in mobile devices. The areas of application of Micro PMT are medical devices, including personal ones.

The manufacturer plans to offer two models, one of which will have a built-in power supply. In the manufacture of sensors, semiconductor production technologies are used, due to which their cost is low. The trial sample costs approximately $620.

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