The implantable chip from MicroCHIPS has been successfully tested in humans. Free Technical Library News

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MicroCHIPS implantable chip successfully tested in humans

23.02.2012

MicroCHIPS announced the first successful human clinical trial of an implantable, programmable, wirelessly controlled drug delivery device. MicroCHIPS specializes in the development of such devices and implantable biosensors.

The subjects were elderly women who had been diagnosed with osteoporosis. With the help of a microchip, they regularly received the daily dose of the required drug. At the same time, a safe level of the drug, necessary for therapeutic indications, was maintained in the blood of patients - the same as as a result of multiple subcutaneous injections usually used in this case. Implantation, performed under local anesthesia, took less than half an hour.

The main goal of the study was a clinical trial of development in terms of pharmacokinetics. Safety measures included constant monitoring of the status of the implanted device and the level of the drug in the blood. The researchers called the analysis of the biological activity of the drug, the assessment of the reliability of the device and the repeatability of delivery operations as a secondary goal.

MicroCHIPS is now developing a device that can hold 400 doses of drug, which could be enough to last a year or more. The presence of wireless control allows doctors to change the dose and delivery interval remotely. The initial development of the microreservoirs and the opening mechanism, which was subsequently licensed by MicroCHIPS, was carried out by the Massachusetts Institute of Technology.

The company expects to apply for the use of the development in the first serial device in 2014.

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