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Airplane comfort and dryness

28.10.2001

An adult human is 60% water. With exhaled air and evaporation through the skin, each of us releases about 100 ml of water per hour - half a glass.

Therefore, in a Boeing that takes 350 passengers on board and delivers them from London to Sydney in 17 hours, approximately 600 liters of water accumulates in the gap between the outer durable shell and the inner skin, condensing on cold metal. This does not benefit aircraft structures and cables laid between the walls. It is believed that due to water condensation in the hull, a DC-11 liner of the Swiss company Swissair could have died a few years ago off the coast of America. Sometimes the moisture accumulated in the tail unit freezes and the rudders stop turning.

It is also important that the humidity in the cabin drops to 20%, while 40% is considered comfortable humidity. The Swedish company CTT Systems has developed an installation that removes this problem. Air from the cabin is passed through a moisture absorber - silica gel and enters the gap between the walls. There, dry air picks up moisture condensed on the walls and returns it to the passenger compartment.

So far, the new installations, costing from 40 to 120 thousand dollars, depending on the size of the liner, have been installed on their aircraft by KLM, Swissair and Lufthansa.

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GMO human liver grown 09.08.2019

Researchers at the University of Pittsburgh have grown miniature human livers from genetically engineered cells for the first time in the lab.

The organoids will serve as a model for non-alcoholic fatty liver disease (NAFLD). This disease is associated with excessive accumulation of fat in the body and can lead to cirrhosis and liver failure.

At the first stage, the team took human skin cells and genetically modified them, introducing a switch that weakens the SIRT1 gene. Then the cells were "rebooted", returning them to the stem stage, and development was directed along a different path. The resulting hepatocytes were implanted into a scaffold of a rat liver, purified from its own cells.

Due to the presence of a scaffold, the cells formed miniature analogues of the human liver with blood vessels and other structures.
This compares favorably with the new development from traditional organelles - tiny structures that consist of the cells of a specific organ, but do not repeat its structure.

Once the mini-liver had formed, the researchers turned on the switch that silenced the SIRT1 gene. As a result, the organ showed metabolic disorders characteristic of NAFLD. The team used the mini-organ to test the drug resveratrol, which showed promise in mice but failed in human clinical trials.

The study confirmed that resveratrol is not useful for the treatment of NAFLD in humans. And made it clear why. The drug increases the activity of the SIRT1 protein, and not the corresponding gene. However, if the expression of SIRT1 is suppressed, then there is no protein that can be affected.

The authors of the work note that the mini-liver is not suitable for transplantation. However, its use as a test bed for new drugs will allow the development of new approaches to the treatment of a number of diseases.

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